Changes in the expression of PD-1 and CA125 in peripheral blood before and after laparoscopic surgery in patients with infertility complicated with stage Ⅰ and Ⅱ endometriosis and their combined diagnostic value
Objective To analyze the changes of programmed mortality factor-1(PD-1)and cancer antigen 125(CA125)expres-sion in peripheral blood before and after laparoscopic surgery in patients with infertility complicated with stage Ⅰ and Ⅱ.endometriosis(EMS),and to explore their clinical significance.Method A total of 32 patients with infertility complicated with stage Ⅰ and Ⅱ.EMS confirmed by pathological examination were selected as the study group in our hospital from July 2020 to June 2022,and 30 pa-tients with infertility diagnosed by clinical diagnosis excluding EMS were selected as the control group,all underwent laparoscopic sur-gery,and the expression levels of peripheral venous blood PD-1 and CA125 in the two groups were examined and compared before sur-gery,1 week after surgery and 1 month after surgery.Results The levels of peripheral blood PD-1 between groups and at different time points were statistically significant(P<0.05),compared with preoperative,the levels of PD-1 in the two groups after surgery were re-duced,and the levels of PD-1 at each time point in the group were statistically different(P<0.05),and PD-1 in the study group was higher than that in the control group(P<0.05).The level of CA125 decreased after surgery between the two groups,and there were significant differences between the two time points(P<0.05).Conclusion The expression levels of PD-1 in peripheral blood before surgery and CA125 are basically normal in patients with infertility and stage Ⅰ and Ⅱ.EMS,which can provide a reference for the preoperative diagnosis of patients with infertility and stage Ⅰ and Ⅱ.EMS to a certain extent.
InfertilityEndometriosisLaparoscopeProgrammed death factor 1Cancer antigen 125
万方数据
维普
