Finding the Underlying Mechanism of Carotid Atherosclerosis in Primary Sjogren's Syndrome Based on Bioinformatics
Objective To uncover key signaling molecules that contribute to the occurrence of carotid artery atherosclerosis in Sjögren syndrome,providing a bioinformatics foundation for a deeper understanding of the pathological process.Method We utilized the GEO database,employing data from carotid artery atherosclerosis specimens(GSE12128)and primary Sjögren syndrome multi-omics chips(GSE84844).Differential expression genes between the two sets of gene chips were screened using the GEO2R tool,and GEO and pathway analyses were conducted using the Daivid database.The differential gene data were visualized using Cytoscape,and core genes were selected using cytohubbe.Results A total of 372 downregulated genes were revealed,with 10 core genes identified based on high connectivity.We found G protein-coupled receptor activation pathways,dopaminergic synapses,and neuroactive recep-tor-ligand activation.Conclusion Among them,the overexpression of GNGT1 may represent a potential mechanism for the occurrence of carotid artery atherosclerosis in Sjögren syndrome,with pathways associated with G protein-coupled receptor activation,dopamine synapses,and neuroactive receptor-ligand activation.
NETL
NSTL
万方数据
