The effect of high-dose binary therapy eradication of H.pylori on intestinal microecology and the corre-sponding probiotic intervention effect
Objective To explore the effect of H.pylori eradication on intestinal microecology and the intervention effect of corre-sponding probiotics.Method 100 patients with H.pylori infection admitted to Longyan First Hospital from October 2023 to April 2024 were included,and they were divided into two groups with 50 cases each using random search method.The control group received high dose biplet and the study group received high dose biplet+probiotics.The Hp eradication rate,intestinal microecological flora,com-pliance,and adverse reactions were compared of two groups.Results The Hp eradication rate in the study group was higher,but the difference was not statistically significant(P>0.05),Before treatment,there was no statistically significant difference in the intestinal microecological flora between the two groups(P>0.05),After treatment,Enterococcus levels in the study group were(7.62±0.96)lgCFU/g,the level of bifidobacteria was(8.67±0.98)lgCFU/g,the level of L.lactis was(8.57±0.62)lgCFU/g,the level of enterobacteria was(6.98±0.86)lgCFU/g,All levels were higher than those in the control group,The difference showed statistical sig-nificance(t=2.593,4.956,8.861,2.156,P<0.05),the compliance rate of the research group was relatively high,and the differ-ence was statistically significant(P<0.05),there was no statistically significant difference in adverse reactions compared(P>0.05).Conclusion Treatment of H.pylori infection with high-dose combination therapy can improve Hp eradication rate and improve intesti-nal microecological flora,thus improving treatment compliance with low adverse effects.
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