The expression and significance of autophagy related protein LC3 in multiple myeloma
Objective To investigate the expression of microtubule associated protein 1 light chain 3(LC3)in multiple myeloma(MM)and further explore its relationship with multiple myeloma diseases.Method Through prospective analysis of autophagy protein levels in newly diagnosed patients with multiple myeloma in our hospital,we compared them with the normal population and analyzed the differences in protein expression levels in patients with multiple myeloma.Results The expression levels of LC3 Ⅰ and LC3 Ⅱ pro-teins decreased in multiple myeloma(P<0.05).The expression of LC3 Ⅰ and LC3 Ⅱ was positively correlated(r=0.777,P=0.000).Conclusion Autophagy protein LC3 is correlated with the occurrence and development of multiple myeloma.
Multiple myelomaMicrotubule associated protein 1 light chain 3Expression
万方数据
维普
