Effect of citicoline injection combined with cognitive training on mild cognitive impairment in Parkinson's disease
Objective To investigate the effect of citicoline injection combined with cognitive training on mild cognitive impairment in Parkinson's disease.Method This study identified 80 patients with mild cognitive impairment in Parkinson's disease from January 2022 to December 2023 were selected as study subjects.These patients were divided into control group and observation group with 40 cases in each group by random number table method.Patients in the control group will receive citicoline injection combined with the u-sual rehabilitation intervention,while patients in the observation group will receive additional cognitive training therapy in addition to the control group.Before and after treatment,a number of indicators such as quality of life scale,Parkinson's Disease Rating Scale,Simple mental State Scale,Montreal Cognitive Assessment Scale and Barthel index score of activities of daily living were evaluated to evaluate the clinical efficacy of the two treatment methods,and the adverse reactions of patients in the two groups during treatment were recorded in detail.Results The overall therapeutic effect of the observation group significantly better than that of the control group(P<0.05).In the evaluation after treatment,the scores of various quality of life scales in the observation group were higher than those in the control group,and both groups were higher than before treatment,indicating a more obvious improvement trend in the observation group(P<0.05).At the same time,the Parkinson's disease rating scale score of the observation group was lower than that of the control group and before treatment(P<0.05).After treatment,the scores of the Simple mental State Examination Scale,the Montreal Cognitive Assess-ment Scale and the Barthel index of activities of daily living in both groups were increased,and the scores of the observation group were higher than those of the control group and before treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Citicoline injection combined with cognitive training is effective in the treat-ment of mild cognitive impairment in Parkinson's disease,which can effectively improve the clinical symptoms and intelligence level of patients,and improve their cognitive function and activities of daily living ability.It has a high implementation safety,and can provide a new treatment idea for clinical treatment.
Citicoline for injectionCognitive trainingParkinson's disease mild cognitive impairment
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维普
