The efficacy of probiotics combined with mesalazine enteric-coated tablets in the treatment of ulcerative co-litis and the effects on the distribution of intestinal flora
Objective To investigate the efficacy of probiotics combined with mesalazine enteric-coated tablets in the treatment of ulcerative colitis and the effect on the distribution of intestinal flora.Method 112 cases of ulcerative colitis patients admitted to our hospital were selected as research object,and divided into observation group and control group,56 cases in each group.The control group was treated with mesalazine,and the observation group added probiotic preparation.The clinical efficacy,inflammatory factors,intestinal flora distribution,immune function,and treatment safety of the two groups were evaluated.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).Bifidobacteria and Lactobacillus in the observation group were higher than those in the control group after treatment,while E.coli and Salmonella were lower than those in the control group(P<0.05).After treatment,the levels of inflammatory factors Toll-like receptor 4(TLR4),galectin-3(Galectin-3),and hypoxia-induc-ible factor-1α(HIF-1α)were lower in the observation group than in the control group(P<0.05).After treatment,the immune func-tion of complement C3,complement C4,CD40 cells in the observation group was lower than that of the control group,and NK cells were higher than that of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reac-tions between the two groups(P>0.05).Conclusion Probiotics combined with mesalazine enteric-coated tablets are effective in the treatment of ulcerative colitis,which can optimise the distribution of intestinal flora in patients,inhibit inflammatory reactions,enhance the immune function of patients,and have a low incidence of adverse reactions.
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维普
