首页|持续性非卧床腹膜透析肾性贫血患者中医证型分布特征及相关性研究

持续性非卧床腹膜透析肾性贫血患者中医证型分布特征及相关性研究

Study on the distribution characteristics and correlation of Chinese medicine patterns in patients with CAPD renal anemia

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目的:探讨持续性非卧床腹膜透析(CAPD)合并肾性贫血患者中医证型分布特征及与各指标的关系.方法:选取 292 例在安徽中医药大学第一附属医院行CAPD治疗且时间大于 3 个月患者,收集患者人口学特征及临床资料,依据住院期间是否发生贫血分为肾性贫血组(n=274)和非肾性贫血组(n=292),比较两组性别、年龄、实验室指标等因素的关系,并观察肾性贫血组中医证型分型特征.结果:所有患者中本虚证、标实证分布分别以脾肾气虚证、血瘀证占比最多.透析龄、天门冬氨基转移酶、血白蛋白、血总钙、超敏 C 反应蛋白、甲状旁腺素、血红蛋白在本虚证中分布情况比较,差异有统计学意义(P<0.05),甲状旁腺素在标实证中分布情况比较,差异有统计学意义(P<0.05).多元 Logistic 回归显示,血白蛋白是CAPD合并肾性贫血患者的保护因素,差异有统计学意义(P<0.05),血肌酐是 CAPD合并肾性贫血患者的危险因素(P<0.05);受试者工作特征曲线(ROC)显示,血白蛋白预测CAPD合并肾性贫血的最佳截断值为 33.95 g/L,曲线下面积(AUC)为0.821,灵敏度为 68.6%,特异性为 88.9%,差异有统计学意义(P<0.05);血肌酐预测CAPD合并肾性贫血的最佳截断值为638.10 μmol/L,AUC为 0.722,灵敏度为 69.7%,特异性为 66.7%,差异有统计学意义(P<0.05);二者联合预测CAPD合并肾性贫血的AUC为 0.889,灵敏度为 89.9%,特异性为 78.8%,差异有统计学意义(P<0.05).结论:CAPD肾性贫血患者中医证型的分布以脾肾气虚证、血瘀证为主,透析龄、天门冬氨基转移酶、血白蛋白、血总钙、超敏C反应蛋白、甲状旁腺素、血红蛋白在中医证型中的分布具有差异性.血白蛋白、血肌酐可作为预测CAPD患者合并肾性贫血的指标之一,且二者联合检测准确度更高.
Objective To investigate the distribution of Chinese medicine patterns in patients with continuous ambulatory peritoneal dialysis(CAPD)combined with renal space anemia,and their relationship with various indicators.Method 292 patients were selected from the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine who had been treated with CAPD for more than 3 months,and the demographic characteristics and clinical data of the patients were collected,and they were divided into renal anemia group(n=274)and non-renal anemia group(n=292)according to the occurrence of anemia during the hospitalization period,compa-ring the relationship between the two groups in terms of gender,age,laboratory indexes,and other factors,and observing the charac-teristics of the traditional Chinese medicine pattern distribution in the renal anemia group.Results Among all patients,the distribution of this deficiency and the standardized solid evidence were most occupied by spleen and kidney qi deficiency and blood stasis,respec-tively.There were significant differences in the distribution of dialysis age,aspartate aminotransferase,blood albumin,total blood cal-cium,ultrasensitive C-reactive protein,parathyroid hormone,and comment hemoglobin in this deficiency evidence(P<0.05)and par-athyroid hormone in the standard evidence(P<0.05).Multiple logistic regression showed that blood albumin was a protective factor for patients with CAPD combined with renal anemia(P<0.05),and blood creatinine was a risk factor for patients with CAPD combined with renal anemia(P<0.05);the ROC curve showed that the best cut-off value of blood albumin for predicting CAPD combined with renal anemia was 33.95 g/L,with an AUC of 0.821,sensitivity of 68.6%,and specificity of 88.9%(P<0.05);the best cut-off val-ue of blood creatinine for predicting CAPD combined with renal anemia was 638.10 μmol/L,with an AUC of 0.722,sensitivity of 69.7%,and specificity of 66.7%(P<0.05);the combination of the two predicted CAPD combined with renal anemia with an AUC of 0.889,sensitivity of 89.9%,and specificity of 78.8%(P<0.05).Conclusion The distribution of Chinese medicine patterns in pa-tients with renal anemia in CAPD was dominated by spleen and kidney qi deficiency patterns and blood stasis patterns,and the distri-bution of dialysis age,aspartate aminotransferase,blood albumin,blood total calcium,ultrasensitive C-reactive protein,parathyroid hormone,and hemoglobin in Chinese medicine patterns form different.Blood albumin and blood creatinine can be used as one of indi-cators for predicting combined renal anemia in patients with CAPD,and the accuracy of their combined testing is higher.

Continuous ambulatory peritoneal dialysisRenal anemiaChinese medicine evidenceRelated factors analysis

葛永、王亿平

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安徽中医药大学第一临床医学院,安徽 合肥 230000

安徽中医药大学第一附属医院肾内科

持续性非卧床腹膜透析 肾性贫血 中医证型 相关因素分析

2025

吉林医学
吉林省人民医院

吉林医学

影响因子:0.926
ISSN:1004-0412
年,卷(期):2025.46(1)