Objective To explore the clinical efficacy of nebulized budesonide combined with acetylcysteine in the treatment of NRDS and its impact on blood gas analysis indicators and inflammatory cytokine levels in pediatric patients.Method According to the random number table method,NRDS patients admitted to the First Affiliated Hospital of Gannan Medical College from September 2021 to June 2023 who met the inclusion criteria were divided into two groups(a control group of 23 cases and an experimental group of 23 cases).After admission,all children were given continuous positive airway pressure ventilation through the nose.If the nasal continu-ous positive airway pressure ventilation pressure was≥6 cm H2 O and the inhaled oxygen concentration was＞0.3,natural pulmonary surfactant replacement therapy was given;The control group was treated with nebulized budesonide inhalation,while the experimental group was treated with acetylcysteine in combination with the above foundation;Both groups received continuous treatment until the dis-ease stabilized or the patient experienced an endpoint event(death).Compare the clinical efficacy of two groups of pediatric patients after 5 days of treatment,including blood gas analysis index,inflammatory factor levels,incidence of bronchopulmonary dysplasia,and non-invasive assisted ventilation time before and after treatment.Results After 5 days of treatment,the clinical efficacy of the experi-mental group was more significant than that of the control group(P＜0.05).After 5 days of treatment,the pH and arterial oxygen par-tial pressure of both groups significantly increased compared to before treatment,and the experimental group was significantly higher than the control group after treatment(P＜0.05);After 5 days of treatment,both groups showed a significant decrease in arterial car-bon dioxide partial pressure,and after 5 days of treatment,the experimental group was significantly lower than the control group(P＜0.05).After 5 days of treatment,the white blood cell count,procalcitonin and C-reactive protein levels in both groups were significantly reduced compared to before treatment(P＜0.05),and the experimental group was significantly lower than the control group after treat-ment(P＜0.05).The non-invasive assisted ventilation time of the experimental group was significantly shorter than that of the control group(P＜0.05).There was no significant difference in the incidence of bronchopulmonary dysplasia between the two groups(P＞0.05).Conclusion The combination of budesonide and acetylcysteine nebulization inhalation has a definite therapeutic effect on neo-natal respiratory distress syndrome,which can significantly improve blood gas analysis in children,regulate inflammatory factor levels,shorten non-invasive auxiliary ventilation time,and have good safety.
Neonatal respiratory distress syndromeAcetylcysteine for inhalationBudesonide suspension
维普
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