摘要
目的 探讨上海市松江区居民大肠癌的危险因素.方法 采用病例对照研究方法,对研究对象的大肠癌危险因素进行单因素和多因素分析.结果 单因素分析发现,病例组和对照组居民的慢性腹泻史、黏液或(和)血便史、肠息肉史、癌症史、吸烟行为、大便隐血实验、一级亲属肠癌史、吸烟状况的差异均有统计学意义(P<0.05).多因素分析发现,慢性便秘史、一级亲属肠癌、肠息肉均为大肠癌的独立危险因素.结论 有慢性便秘史和肠息肉病史、一级亲属有肠癌病史者人群的大肠癌发病风险将明显增加,并且应重视吸烟行为对大肠癌的影响.
Abstract
Objective To explore the risk factors for colorectal cancer among residents in Songjiang District,Shanghai.Methods A case-control study was conducted to conduct univariate and multivariate analyses of the risk factors for colorectal cancer among the study subjects.Results The univariate analysis showed that there were statistically significant differences(P<0.05)in the history of chronic diarrhea,history of mucous or/or bloody stools,history of intestinal polyps,history of cancer,smoking behavior,fecal occult blood test,history of colorectal cancer in first-degree relatives,and smoking status between the case group and the control group residents.Multivariate analysis found that a history of chronic constipation,first-degree relatives with colorectal cancer,and intestinal polyps were all independent risk factors for colorectal cancer.Conclusion Individuals with a history of chronic constipation and intestinal polyps,as well as first-degree relatives with a history of colorectal cancer,have a significantly increased risk of developing colorectal cancer,and attention should be paid to the impact of smoking behavior on colorectal cancer.
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