Study of population pharmacokinetics of mycophenolate mofetil in pa-tients with primary nephrotic syndrome
Objective To study population pharmacokinetic model of mycophenolate mofetil (MMF) in primary nephrot-ic syndrome (PNS) in order to provide a reference for clinical personalized medication. Methods From January 2011 to February 2014,56 patients with PNS admitted into our hospital were selected as observation objects during the study. Symptomatic treatment of MMF was provided in all participants,and then blood samples were collected.Population pharmacokinetic model of MMF was constructed by nonlinear mixed effect model aiming at exploring the influences of patient’s age,gender,height,weight,dosage,serum creatinine,and treatment time on the pharmacokinetic parameters. Re-sults Two-compartment model of first-order absorption and elimination in pharmacokinetic basic model were most ef-fective.Weight and treatment time were principal factors in MMF clearance rate.The final population pharmacokinetic model: clearance rate = 0.476ítotal body weightí(1-e-1.17POD). Conclusion MMF is representative in pharmacokinetic model in PNS and provides the basis for determining individualized dosage regimen.
Mycophenolate moftilPopulation pharmacokineticsNonlinear mixed effect model
国家科技期刊平台
NSTL
万方数据
维普
