Efficacy observation of different cut-off values of tumor abnormal pro-tein in screening lung cancer
Objective To explore the efficacy of different cut-off values of tumor abnormal protein(TAP)in screening lung cancer.Methods A total of 66 lung cancer patients and 66 non-lung cancer patients admitted to Jiangxi Chest Hospital from January 2021 to January 2022 were selected as the research objects.The area difference of TAP aggregate between lung cancer patients and non-lung cancer patients was calculated to determine whether TAP can be used to diagnose lung cancer.The optimal cut-off value of TAP was obtained by drawing the ROC curve to diagnose lung cancer and determine the diag-nostic efficiency.The diagnostic efficiency was compared with the clinical common TAP normal reference range(＜121 μm2).Results TAP condensed area of lung cancer group is greater than the lung cancer group,and the difference was statistically significant(P＜0.05).By drawing the ROC curve,the highest cut-off value＞170 μm2 was determined,and the diagnostic efficacy was compared with the normal reference range of TAP(＜121 μm2).The results showed that there were no signifi-cant differences in the positive detection rate,sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic coincidence rate between the two groups(P＞0.05).Conclusion Different cut-off values of TAP are used to screen suspected lung cancer patients,and the screening effect is better with the cut-off value of 170 μm2,which is worthy of clinical application.
Tumor abnormal proteinCut-off valueScreening for lung cancerDiagnostic efficacy
国家科技期刊平台
NSTL
万方数据
维普
