Objective To analyze the risk factors of postoperative incision infection in surgical patients.Methods The clin-ical data of 256 patients who received surgical treatment in Jiujiang First People's Hospital from January 2022 to December 2022 were retrospectively analyzed.All the selected patients received corresponding surgical treatment.They were grouped according to the incidence of postoperative incision infection.The relevant data of the two groups were compared,and the relevant factors of surgical incision infection were analyzed.Rsults Among the 256 patients,20 developed incision infection,and the incidence of postoperative incision infection was 7.81%(20/256).The results of univariate analysis showed that the proportion of age>60 years old,diabetes mellitus,preoperative anemia,operation time ≥3 h,emergency operation and pe-rioperative blood transfusion in the infected group were higher than those in the uninfected group,with statistical signifi-cance(P<0.05).Logistic regression analysis showed that age>60 years old(OR=6.316,95%CI=2.214-18.018,P=0.001),complicated diabetes mellitus(OR=4.787,95%CI=1.877-12.209,P=0.001),preoperative anemia(OR=4.756,95%CI=1.860-12.163,P=0.001),operation time≥3 hours(OR=6.367,95%CI=2.458-16.491,P<0.001),emergency operation(OR=6.574,95%CI=2.547-16.968,P<0.001)and perioperative blood transfusion(OR=5.441,95%CI=2.111-14.024,P<0.001)were independent risk factors for postoperative incision infection in surgical patients(P<0.05,OR>1).Conclusion Surgery is an important treatment method,but because of its own trauma,the incidence of postoperative incision infection is high.For patients aged>60 years,with diabetes,preoperative anemia,operation time ≥3 h,emergency surgery,and periop-erative blood transfusion,it is necessary to focus on management to reduce the incidence of incision infection as much as possible.