摘要
目的 分析肾细胞癌(RCC)患者的临床资料及检验检查结果,探讨其发生的危险因素.方法 回顾性分析2007年1月至2021年6月广州市第十一人民医院诊断的76例RCC患者的临床资料,所有患者经随访手术病理证实RCC,收集相关资料及检验检查结果,包括合并症(糖尿病、高血压病、其他恶性肿瘤等)、血压(BP)、血糖、血脂、体重指数(BMI)和血尿酸(UA),在病例库中根据年龄、性别因素进行匹配选取影像学检查肾正常、肾囊肿、肾血管平滑肌脂肪瘤各76例作为对照,采用多因素logistic回归分析RCC发生的危险因素.结果 RCC组的合并症、高BP、高BMI、高血脂、高血糖、高UA发生率高于对照组,差异有统计学意义(P＜0.05).经多因素logistic回归分析显示,合并症(β=1.34,P=0.006,OR=3.83,95％CI:1.47～9.95)、高 BP(β=0.77,P=0.021,OR=2.15,95％CI:1.12～4.14)和高UA(β=0.72,P=0.015,OR=2.06,95％CI:1.15～3.67)是发生RCC的独立危险因素.结论 有糖尿病、高血压病、恶性肿瘤患者及高BP、高UA的患者容易发生RCC,应警惕和提早预防.
Abstract
Objective The clinical data and examination results of patients with renal cell carcinoma(RCC)were analyzed to explore the risk factors of RCC.Methods The clinical data of 76 patients with RCC diagnosed the 11th People's Hospital of Guangzhou from January 2007 to June 2021 were retrospectively analyzed.All patients were confirmed with RCC by fol-low-up operation and pathology.Relevant data and examination results were collected,including complications(diabetes,hypertension,other malignant tumors,etc.),blood pressure(BP),blood glucose,blood lipid,body mass index(BMI)and blood uric acid(UA).In the case bank,76 cases of normal kidney,renal cyst and renal angiomyolipoma were selected as controls according to age and sex factors.Multivariate logistic regression was used to analyze the risk factors of RCC.Results The incidence of comorbidities,high BP,high BMI,high lipids,high blood sugar and high UA in RCC group was higher than that in control group,and the differences were statistically significant(P＜0.05).Multivariate logistic regression analysis showed that complications(β=1.34,P=0.006,OR=3.83,95％CI:1.47-9.95)and high BP(β=0.77,P=0.021,OR=2.15,95％CI:1.12-4.14)and high UA(β=0.72,P=0.015,OR=2.06,95％CI:1.15-3.67)were independent risk factors for RCC.Conclusion Patients with diabetes,hypertensive disease,malignancy,or high blood pressure or high uric acid are prone to RCC.It should be vigilant and early prevention.
基金项目
广东省广州市科技计划项目(202102080629)
维普
万方数据