Effect of acupuncture combined with Hydroxychloroquine Sulfate on the ratio of T helper cell 17/regulatory T cells in patients with primary Sjogren's syndrome
Objective To observe the effect of acupuncture combined with Hydroxychloroquine Sulfate(HCQ)on the ratio of T helper cell 17(T-17)/regulatory T cell(Treg)in patients with primary Sjogren's syndrome.Methods A total of 52 patients of primary Sjogren syndrome admitted to Shanxi Chinese Medicine Hospital from December 2019 to December 2020 were selected as the research subjects,and they were divided into treatment group(26 cases)and control group(26 cases)according to random number table.The control group patients were given oral HCQ,while the treatment group patients were treated with acupuncture in addition to the control group.The clinical efficacy and traditional Chinese medicine(TCM)syndrome scores,tear flow rate,saliva flow rate,levels of erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),serum immunoglobulin G(IgG)and Th17/Treg ratio were compared between the two groups before and after treatment.Re-sults The total clinical effective rate of patients in the treatment group after treatment was higher than that in the control group,and the difference was statistically significant(P＜0.05).After treatment,the TCM syndrome score of the treatment group was lower than that of the control group;the tear flow rates,saliva flow rates were higher than those of the control group;the levels of ESR,CRP,IgG were lower than those of the control group;and the Th17/Treg ratios was lower than that of the control group,the differences were statistically significant(P＜0.05).Conclusion Acupuncture combined with HCQ is effective,safe and reliable in the treatment of patients with primary Sjogren's syndrome.It can significantly improve the symptoms of dry mouth and dry eyes,reduce the immune response,reduce TCM syndrome points,increase the tear flow rate and saliva flow rate,reduce the Th17/Treg ratio and regulate the immune function.
Primary Sjogren's syndromeAcupunctureHydroxychloroquine SulfateT helper cell 17/regulatory T cell
万方数据
维普
