Effect of salt restriction intervention on the therapeutic effect and glucose and lipid metabolism of hypertensive patients with diabetic kidney disease in the platform of National Metabolic Management Center
Objective To explore the effect of salt restriction intervention on the therapeutic effect and glucose and lipid metabolism of hypertensive patients with diabetic kidney disease in the platform of National Metabolic Management Center(MMC).Methods A total of 126 patients with hypertension combined with DKD admitted to the Third Hospital of Nanchang from January 2021 to December 2021 were selected as the study objects,and were divided into observation group(66 cases)and control group(60 cases)according to the coin tossing method.Patients in the control group received routine antihyper-tensive,hypoglycemic,lipid-lowering and anticoagulation treatment.On the basis of the control group,the observation group received intensive salt restriction(3-4 g)intervention,which was jointly managed by MMC platform.Urinary albumin/crea-tinine ratio(UACR),glomerular filtration rate(eGFR),renal function,blood pressure,glycosylated hemoglobin(HbA1c)and quality of life were compared between the two groups.Results The UACR and eGFR levels in observation group were lower than those in control group after intervention,and the differences were statistically significant(P＜0.05).The UACR and eGFR levels in two groups after intervention were lower than those before intervention,and the differences were statistically significant(P＜0.05).The levels of serum creatinine(Cr),blood urea nitrogen(BUN)and β 2-microglobulin(β 2-MG)in observation group were lower than those in control group after intervention,and the differences were statistically significant(P＜0.05).The levels of Cr,BUN and β 2-MG in two groups after intervention were lower than those before in-tervention,and the difference was statistically significant(P＜0.05).Blood pressure and HbA1c levels in the observation group after intervention were lower than those in the control group,and the differences were statistically significant(P＜0.05).The blood pressure and HbA1c levels in the two groups after intervention were lower than those before intervention,and the differences were statistically significant(P＜0.05).The scores of mental health,social function,physiological func-tion and physiological function in the MOS item short form health survey(SF-36)scale of the observation group after inter-vention were higher than those of the control group,with statistically significant differences(P＜0.05).And the scores of mental health,social function,physiological function and physiological function of the two groups after intervention were higher than those before intervention,with statistically significant differences(P＜0.05).Conclusion Salt restriction inter-vention can effectively reduce the levels of UACR and eGFR in patients with hypertension and DKD on MMC platform,im-prove renal function,regulate blood pressure and blood glucose levels,and improve the quality of life.
Salt restrictionNational Metabolic Management CenterHigh blood pressureDiabetic kidney diseaseGlu-cose and lipid metabolismRenal functionQuality of life
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