Application of adjustable pressure shunt tube in the treatment of Crypto-icoccus neoformans meningitis with intracranial hypertension
Objective To study the application of adjustable pressure shunt tube in the treatment of Cryptococcus meningi-tis with intracranial hypertension.Methods Forty patients with Cryptococcus meningitis complicated with intracranial hy-pertension treated in Ganzhou People's Hospital from July 2020 to December 2022 were selected as the study objects,and were divided into experimental group(n=20)and control group(n=20)according to random number table method.The ex-perimental group received ventriculoperitoneal shunt treatment with antifungal drugs+adjustable pressure shunt tube,and the control group received ventriculoperitoneal shunt treatment with antifungal drugs+fixed pressure shunt tube.The clinical efficacy,hospitalization days,antifungal drug use days,clinical indicators(intracranial pressure,cryptococcus count in cere-brospinal fluid)before treatment and 1 week after treatment,incidence of postoperative complications(subdural hemorrhage,extraveicular blood,intracranial infection)between the two groups were compared.Results The therapeutic effect of experi-mental group was better than that of control group,and the difference was statistically significant(P＜0.05).The days of hospitalization and the days of antifungal drug use in experimental group were shorter than those in control group,and the differences were statistically significant(P＜0.05).Before treatment,there was no significant difference in intracranial pres-sure and the number of Cryptococcus in cerebrospinal fluid between the two groups(P＞0.05).After 1 week of treatment,the intracranial pressure and the number of Cryptococcus in cerebrospinal fluid in the two groups were lower than before treat-ment,and the experimental group was lower than the control group,with statistical significance(P＜0.05).The incidence of subdural hemorrhage in experimental group was lower than that in control group,and the difference was statistically signifi-cant(P＜0.05).There were no significant differences in the incidence of external ventricular blood and intracranial infection between the two groups(P＞0.05).The total complication rate of experimental group was lower than that of control group,and the difference was statistically significant(P＜0.05).Conclusion Adjustable pressure shunt tube can effectively im-prove the clinical symptoms of Cryptococcus meningitis patients with intracranial hypertension,effectively control intracra-nial pressure,shorten the treatment period,improve the clinical cure rate,reduce the incidence of complications,and facili-tate the prognosis and recovery of the patients.
Adjustable pressure shunt tubeComplicated with intracranial hypertensionCryptococcus meningitisAnti-fungal drugsVentriculoperitoneal shunt
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维普
