藤甲酸氯化钠配合抗人乳头瘤病毒生物蛋白敷料治疗宫颈鳞状上皮内病变人乳头瘤病毒感染患者的效果

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中文摘要：目的探讨藤甲酸氯化钠配合抗人乳头瘤病毒(HPV)生物蛋白敷料治疗宫颈鳞状上皮内病变HPV感染患者的效果。方法选取2022年9月至2023年3月牡丹江医学院附属红旗医院妇产科收治的100例子宫颈鳞状上皮内病变HPV感染患者作为研究对象，按照随机数字表法分为对照组(50例)与试验组(50例)。对照组采用抗HPV生物蛋白敷料治疗，试验组采用抗HPV生物蛋白敷料及藤甲酸氯化钠静脉滴注治疗，比较两组的HPV转阴率、HPV有效率、HPV病毒载量转归有效率、阴道微生物平衡恢复率、实验室指标[白细胞介素-4(IL-4)、白细胞介素-12(IL-12)、γ干扰素(IFN-y)]水平。结果试验组患者HPV转阴率、总有效率高于对照组，差异有统计学意义(P＜0。05)。试验组患者HPV病毒载量转归总有效率高于对照组，差异有统计学意义(P＜0。05)。试验组患者阴道微生物平衡恢复率高于对照组，差异有统计学意义(P＜0。05)。治疗后，两组患者IL-4低于本组治疗前，IL-12、IFN-γ高于本组治疗前，且试验组患者IL-4低于对照组，IL-12、IFN-γ高于对照组，差异有统计学意义(P＜0。05)。结论藤甲酸氯化钠联合抗HPV生物蛋白敷料治疗子宫颈鳞状上皮内病变HPV感染，HPV转阴率、治疗有效率、阴道微生物平衡恢复率更大，实验室指标水平改善幅度更大。

外文标题：Effect of sodium citrate sodium chloride combined with anti-human pa-pillomavirus bioprotein dressing in the treatment of human papillo-irfectioicervimavirus infection in cervical squamous intraepithelial lesions

外文摘要：Objective To investigate the effect of sodium citrate sodium chloride combined with anti-human papillomavirus(HPV)bioprotein dressing in the treatment of HPV infection in cervical squamous intraepithelial lesions.Methods A total of 100 patients with HPV infection in cervical squamous intraepithelial lesions were admitted to the Hongqi Hospital Affiliated to Mudanjiang Medical University from September 2022 to March 2023 as the study objects,and divided into control group(50 cases)and test group(50 cases)according to random number table method.The control group was treated with an an-ti-HPV biological protein dressing,and the test group was treated with sodium citrate sodium chloride combined with an-ti-human papillomavirus bioprotein dressing,HPV negative converse rate,HPV effective rate,HPV viral load conversion rate,vaginal microbial balance recovery rate,the level of laboratory indicators(interleukin-4[IL-4],interleukin-12[IL-12],and interferon-γ[IFN-γ])were compared between the two groups.Results HPV negative converse rate and total effec-tive rate in test group were higher than those in control group,and the differences were statistically significant(P＜0.05).The total effective rate of HPV viral load con-version in test group was higher than that in control group,and the difference was statistically significant(P＜0.05).The recovery rate of vaginal microbial balance in test group was higher than that in control group,and the difference was sta-tistically significant(P＜0.05).After treatment,IL-4 was lower than that before treatment,IL-12 and IFN-γ were higher than those before treatment,and IL-4 in test group was lower than that of control group,IL-12 and IFN-γ were higher than those of control group,the differences were statistically significant(P＜0.05).Conclusion In the treatment of HPV infection in cervical squamous intraepithelial lesions with sodium citrate sodium chloride combined with anti-human papillomavirus bioprotein dressing,HPV negative converse rate,efficacy of treatment,recovery rate of vaginal microbial balance and the improvement of laboratory indicators level are greater.

外文关键词：

Human papillomavirus infection in cervical squamous intraepithelial lesionsSodium citrate sodium chlorideAnti-human papillomavirus bioprotein dressingVaginal microbial balanceinflammatory factor levels

作者：

张亚男、马超群、王天娇

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作者单位：

牡丹江医学院附属红旗医院妇产科,黑龙江牡丹江 157000

关键词：

宫颈鳞状上皮内病变人类乳头瘤病毒感染藤甲酸氯化钠抗人乳头瘤病毒生物蛋白敷料阴道微生物平衡炎症因子水平

基金：

黑龙江省牡丹江市应用技术研究与开发计划项目

项目编号：

HT2022NS075

出版年：

2024

中国当代医药

中国保健协会当代创新（北京）医药科学研究院

中国当代医药

影响因子：1.215

ISSN：1674-4721

年,卷(期)：2024.31(3)

参考文献量21