首页|中药及其单体调控肝癌细胞自噬的研究进展

中药及其单体调控肝癌细胞自噬的研究进展

扫码查看
原文链接
  • 万方数据
  • 维普
自噬在恶性肿瘤的发展和治疗中起非常重要的作用。一方面恶性肿瘤细胞通过自噬过度降解促进细胞分化及诱导肿瘤细胞自噬性死亡，同时在肿瘤发展后期，癌细胞通过自噬降解废弃物以提供能量使其在缺乏营养及缺氧的条件下生存。中医药是中华民族传统文化的瑰宝，作为一种不可或缺的现代抗肿瘤治疗手段，其具有十分明显的优势，已广泛用于恶性肿瘤的临床治疗，是目前抗肿瘤药物研究的重点与热点。中药及其单体，如姜黄素、大黄素、苦参碱、木犀草素、人参皂苷、紫草多糖、小檗碱、丹酚酸、麦冬皂苷B和小白菊内酯，均对肝癌具有显著的靶向性治疗作用，可有效调节肝癌细胞的自噬能力，抑制肝癌发展，提高患者免疫能力，增加肝癌细胞对化疗及放射治疗的敏感性方面有重要价值，可单独或联合发挥抗肝癌作用。
Research progress of traditional Chinese medicine and its monomer in regulating autophagy of liver cancer cells
Autophagy plays a very important role in the development and treatment of malignant tumors.On the one hand,malignant tumor cells promote cell differentiation and induce autophagy death through autophagy over-degradation,and at the same time,in the later stage of tumor development,cancer cells degrade waste through autophagy to provide energy for them to survive under the conditions of lack of nutrition and hypoxia.Traditional Chinese medicine is the treasure of Chinese traditional culture.As an indispensable modern anti-tumor treatment method,it has obvious advantages and has been widely used in the clinical treatment of malignant tumors,which is the focus and hot spot of anti-tumor drug research at present.Traditional Chinese medicines and their monomers,such as curcumin,emodin,matrine,luteolin,ginsenoside,Lithospermum polysaccharide,berberine,salvianolic acid,Ophiopogon japonicus saponin B and parthenolide,have significant targeted therapeutic effects on liver cancer,which can effectively regulate the autophagy of liver cancer cells,inhibit the development of liver cancer,improve patients'immunity,and increase the sensitivity of liver cancer cells to chemotherapy and radiothera-py.They can play an important role in anti-liver cancer alone or in combination.

Liver cancerTraditional Chinese medicineChinese medicine monomerAutophagy cellsAnticancer effect

郭锦荣、凌江红

展开 >

上海健康医学院附属周浦医院中医科,上海 201318

肝癌 中药 中药单体 细胞自噬 抗癌作用

上海健康医学院师资人才百人库项目上海市浦东新区卫生健康委员会浦东名中医培养计划项目上海市浦东新区科技和经济委员会民生科研专项资金医疗卫生项目上海市浦东新区卫生健康委员会卫生计生科研项目

B3-0200-20-311008PWRzm2020-16PKJ2019-Y41PW2020A-25

2024

中国当代医药
中国保健协会 当代创新（北京）医药科学研究院

中国当代医药

影响因子：1.215
ISSN：1674-4721
年,卷(期)：2024.31(3)
  • 33