Analysis of influencing factors on liver stiffness measurement in chronic hepatitis B patients with alanine aminotransferase＜2 times the upper limit of normal value
Objective To analyze the influence factors of liver stiffness measurement(LSM)in chronic hepatitis B patients with alanine aminotransferase(ALT)＜2 times the upper limit of normal value(ULN).Methods A total of 250 patients with chronic hepatitis B with ALT＜2 times ULN admitted to Yichun People's Hospital from June 2019 to December 2021 were selected as the study objects.All patients underwent liver transient elastic ultrasound(Fibroscan)examination and patholog-ical examination.The degree of liver fibrosis and the degree of inflammatory activity of the patients were known through pathological examination,and clinical data[gender,course of disease,age,body mass index(BIM),ALT,aspartate amino-transferase(AST),albumin(ALB),total bilirubin(TBil),prothrombin time(PT),Hepatitis B virus DNA(HBV-DNA)]were collected.LSM was compared in patients with different hepatic fibrosis and inflammatory activity,and the related factors af-fecting LSM were analyzed.Results The liver fibrosis stages of 250 patients were S0 in 4 cases(1.60％),S1 in 144 cases(57.60％),S2 in 75 cases(30.00％),and S3 in 27 cases(10.80％).The overall comparison of LSM in patients with different stages of liver fibrosis showed statistically significant differences(P＜0.05),among which,there was statistically significant difference between the S1 stage,S2 stage and S3 stage(P＜0.05),but there was no statistically significant difference between the S0 stage and the S1 stage(P＞0.05),and the LSM from low to high was S1 stage＜S2 stage＜S3 stage.Among the 250 patients,the inflammatory activity levels were 80 cases(32.00％)of G1 degree,128 cases(51.20％)of G2 degree and 42 cases(16.80％)of G3 degree.There was statistical significance in the comparison of LSM among patients with different inflammatory activity levels(P＜0.05),and the LSM levels were G1＜G2＜G3 stage from low to high.LSM was compared in patients with different ages,ALT,AST,PT values,spleen thickness and spleen length,and the differences were statistically significant(P＜0.05).Multiple linear regression analysis showed that age,ALT,AST,PT,degree of inflammatory activity,stage of liver fibrosis,spleen thickness and spleen length were related factors affecting LSM(P＜0.05).Conclusion Fibroscan stiffness measurement has a good diagnostic value for the evaluation of cirrhosis in patients with chronic hepatitis B with ALT＜2 times ULN.The degree of liver in-flammatory activity,stage of liver fibrosis,age,ALT,AST,PT,spleen thickness and spleen length may affect LSM.
Liver transient elastic ultrasoundLiver stiffness measurementAlanine aminotransferaseChronic hepatitis B
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维普
