Effect of Agomelatine on sleep quality and depressive mood in patients with bipolar depression accompanied by disturbed sleep rhythm
Objective To investigate the effects of Agomelatine therapy on sleep quality,depressive mood and estrogen lev-els in patients with bipolar depression accompanied by disturbed sleep rhythm.Methods A total of 54 patients with bipolar disorder admitted to Department of Psychosomatic Medicine,Fuzhou Third Hospital from October 2021 to January 2023 were selected as the study objects.All patients were in a state of mild to moderate depression accompanied by sleep rhythm disturbance.They were divided into control group and observation group according to random number table method,with 27 patients in each group.The control group received conventional drug treatment,and the observation group was additionally given Agomelatine Tablets.Both groups received continuous treatment for 8 weeks.The levels of polysomnography(PSG),Hamilton depression scale(HAMD),self-rating depression scale(SDS),Pittsburgh sleep index scale(PSQI),Epworth sleepiness scale(ESS),serum estradiol(E2),prolactin(PRL)and luteinizing hormone(LH)were compared between the two groups.Results After treatment,the bed time,sleep latency and wake time after sleep in the observation group were shorter than those in the control group,the total sleep time and rapid eye movement latency were longer than those in the control group,the sleep efficiency was higher than that in the control group,and the wake times was less than that in the control group,the differences were statistically significant(P＜0.05).HAMD.SDS,PSQI and ESS scores of the observa-tion group were lower than those of the control group,the differences were statistically significant(P＜0.05).After treatment,the level of E2 in observation group was higher than that in control group,and the level of PR L was lower than that in control group,the differences were statistically signifi-cant(P＜0.05).There was no significant difference in LH between two groups before and after treatment(P＞0.05).Conclu-sion Agomelatine therapy can effectively improve sleep quality,reduce drowsiness,improve estrogen levels and reduce de-pression in patients with bipolar depression accompanied by disturbed sleep rhythm.
万方数据
维普
