Clinical efficacy analysis of Pramexol combined with Metoba in the treat-ment of Parkinson's disease
Objective To explore the clinical effect of Pramexol+Metoba in patients with Parkinson's disease.Methods Seventy patients with Parkinson's disease in the Third People's Hospital of Heze City from February 2019 to May 2022 were selected as research objects and divided into the reference group(n=35)and the study group(n=35)by coin tossing method.The reference group was treated with Metoba alone.The study group was treated with Pramexol combined with Metoba.The total response rate,Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD),unified Parkinson's disease rating scale Ⅲ(UPDRS Ⅲ)and the MOS item short form health survey 36(SF-36)scores of the two groups were compared.Re-sults The total effective rate of treatment in the study group was higher than that in the reference group,the difference was statistically significant(P＜0.05).Before treatment,there were no significant differences in HAMA score and HAMD score between the two groups(P＞0.05).After treatment,HAMA scores and HAMD scores of Parkinson's disease patients in the study group were lower than those in the reference group,and the scores of both groups after treatment were lower than before treatment,with statistical significances(P＜0.05).Before treatment,there was no significant difference in UPDRS Ⅲscores between the two groups(P＞0.05).After treatment,the UPDRS Ⅲ score of Parkinson's disease patients in the study group was lower than that in the reference group,and the UPDRS Ⅲ score in the two groups was lower than that before treatment,with statistical significances(P＜0.05).Before treatment,there were no significant differences in physiological function score,psychological function score,material life score and social function score between the two groups(P＞0.05).After treatment,the physiological function scores,psychological function scores,material life scores and social function scores of Parkinson's disease patients in the study group were higher than those in the reference group,and the scores of two groups were higher than those before treatment,with statistical significance(P＜0.05).Conclusion During the treatment period,the effective application of Pramexol+Metoba combined medication can significantly improve the efficacy of patients with Parkinson's disease,improve the anxiety and depression of patients,control the progression of the disease,and significantly improve the quality of life of patients with Parkinson's disease.
万方数据
维普
