Application effect of prebiotics in stage Ⅳ patients with type 2 diabetic nephropathy
Objective To investigate the application effect of prebiotics in stage Ⅳ patients with type 2 diabetic nephropathy.Methods A total of 80 patients with stage Ⅳ type 2 diabetic nephropathy admitted to the Department of Nephrology,Jiu Jiang NO.1 People's Hospital from June 2020 to June 2022 were selected as research subjects.According to random number table method,the patients were divided into observation group and control group,with 40 cases in each group.The laboratory indexes such as serum albumin(ALB),hemoglobin(Hb),renal function indexes and inflammatory indexes before and after treatment were compared between the two groups.The prognosis indexes such as acute gastrointestinal injury(AGI)score,incidence of complications,and secondary hospitalization rate were compared between the two groups.Results Before treat-ment,there were no statistically significant differences in laboratory indexes between the two groups(P＞0.05).After treat-ment,glycosylated hemoglobin(HbA1c),C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),serum creatinine(SCr)and blood urea nitrogen(BUN)in the observation group were lower than those before treatment,and ALB.Hb and estimated glomerular filtration rate(eGFR)were higher than those before treatment,and the differences were statistically significant(P＜0.05).The CRP of the control group after treatment was lower than that before treatment,and the difference was statistically significant(P＜0.05).There were no significant differences in ALB,HbA1c,Hb,CRP,IL-6,TNF-α,SCr,BUN and eGFR in the control group before and after treatment(P＞0.05).After treatment,the ALB and eGFR of the observation group were higher than those of the control group,and the HbA1c,CRP,IL-6,TNF-α,SCr and BUN were lower than those of the control group,and the differences were statistically significant(P＜0.05).The AGI score,complication rate and secondary hospitalization rate of the observation group were lower than those of the control group,and the gastrointestinal recovery time was shorter than that of the control group,and the dif-ferences were statistically significant(P＜0.05).Conclusion Prebiotics can effectively improve intestinal flora disorder,re-duce toxin accumulation and delay renal function deterioration in patients with type 2 diabetic nephropathy.
Type 2 diabetic nephropathyPrebioticsIntestinal flora disorderIndicators of inflammationRenal function
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