Correlation research between high-risk human papillomavirus genotypes and vaginal microecology in patients with cervical cancer
Objective To analyze the correlation between high-risk human papillomavirus(HPV)genotypes and vaginal microbiota in cervical cancer patients.Methods A total of 110 cervical cancer patients and health checkups from the Jiu-jiang Third People's Hospital from January 2020 to December 2022 were selected as the research subjects.They were divid-ed into a cervical cancer group of 80 patients and a control group of 30 patients based on whether they had cervical cancer.Both groups underwent HPV genotype testing.The high-risk HPV infection status,different clinical stages,tissue types,and differentiation degrees of cervical cancer patients were observed.The vaginal microbiota between the cervical cancer group and the control group was compared.The vaginal microbiota of high-risk HPV genotype patients was compared.Results Among 80 cervical cancer patients,the high-risk HPV infection rate was 88.75％.The top three high-risk HPV genotype infections in the cervical cancer group were HPV 16(58.75％),HPV18(11.25％),and HPV58(7.70％).The ratio of pH ≥4.5,lactobacillus abnormality,bacterial Vaginitis,chlamydia,ureaplasma urealyticum and trichomonas in cervical cancer patients with HPV infection were higher than that in the control group,the differences were statistically significant(P＜0.017).There were no statistically significant differences in the proportion of vaginal pH ≥ 4.5,abnormal lactobacilli,bacte-rial vaginitis,chlamydia,ureaplasma urealyticum,and trichomonas among patients with HPV 16,HPV 18,HPV58,and mixed infection(P＞0.05).HPV16,HPV18,and HPV58 were correlated with pH ≥4.5,abnormal lactobacilli,bacterial vaginitis,chlamydia,ureaplasma urealyticum,and trichomonas(P＜0.05).Conclusion HPV16,HPV18,HPV58,and mixed infections are more common among high-risk HPV genotypes in cervical cancer,and high-risk HPV infection can lead to vaginal microbiota disorders in patients.
Cervical cancerHigh-risk human papillomavirusGenotypeVaginal micro-ecologyRelevance
万方数据
维普
