Objective To explore the application value of Qingyi Decoction combined with Bingxiao Powder for external ap-plication in peripancreatic effusion of acute pancreatitis.Methods A total of 80 cases of acute pancreatitis complicated with peripancreatic effusion admitted in Rizhao Traditional Chinese Medicine Hospital from January 2021 to February 2023 were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was treated with Qingyi Decoction orally,and the observation group was treated with Qingyi Decoction combined with percutaneous external application of Bingxiao Powder.The recovery time of abdominal pain,abdominal dis-tension and bowel sounds,the recovery time of blood amylase and the absorption time of peripancreatic effusion of more than 50%in the two groups were compared.The changes of C-reactive protein level during the treatment were observed and the total incidence of complications and hospitalization time in the two groups were counted.Results The recovery time of ab-dominal pain,abdominal distension and bowel sounds in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The recovery time of blood amylase and the absorption time of more than 50%of peripancreatic effusion in the observation group were shorter than those in the control group,and the dif-ferences were statistically significant(P<0.05).The levels of C-reactive protein in the two groups were lower than those be-fore treatment for 3 and 7 days,and the differences were statistically significant(P<0.05).The levels of C-reactive protein in the observation group were lower than those in the control group for 3 and 7 days,and the differences were statistically significant(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,with statistically significant difference(P<0.05).Conclusion For peripancreatic effusion in acute pancreatitis,oral Qingyi Decoction combined with Bingxiao Powder can promote the recovery of gastrointestinal function,promote the absorption of effusion,inhibit inflammation,reduce complications related to pancreatitis and shorten hospitalization time.