Discussion on the mechanism of notoginseng in the treatment of breast cancer based on network pharmacology and molecular docking
Objective To explore the mechanism of notoginseng in the treatment of breast cancer based on network phar-macology and molecular docking.Methods The effective active components and targets of notoginseng through the Tradi-tional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).Targets related to breast cancer were identified by DisGeNET.The intersection of drug targets and disease targets was analyzed by protein-protein interac-tion networks(PPI)analysis,gene ontology(GO)function enrichment analysis and Kyoto encyclopedia of genes and genomes(KEGG)pathway analysis.Results Eight effective active components of notoginseng,including quercetin,ginsenoside rh2 and beta-sitosterol were obtained,corresponding to 182 targets.Through the DisGeNET database,539 breast cancer related targets and 54 intersection targets were obtained.The PPI analysis showed that tumor protein P53(TP53),AKT serine/thre-onine kinase 1(AKT1)and estrogen receptor 1(ESR1)may be the core targets of the herb in the treatment of the disease.The core components of notoginseng can have good binding activity with the above-mentioned core targets.GO functional enrichment analysis and KEGG pathway enrichment analysis showed that notoginseng played a therapeutic role in breast cancer through 518 GO entries and 128 pathways.Conclusion Notoginseng plays a therapeutic role in breast cancer through multiple effective ingredients,multiple targets and multiple pathways.
NotoginsengBreast cancerNetwork pharmacologyMechanism of action
万方数据
维普
