Objective To explore the clinical effect of high-frequency repetitive transcranial magnetic stimulation(rTMS)therapy on patients with post-stroke depression(PSD).Methods A total of 60 patients with PSD admitted to the Rehabilita-tion Hospital Affiliated to Fujian University of Traditional Chinese Medicine from November 2020 to November 2022 were selected as subjects.They were divided into the study group(30 cases)and control group(30 cases)according to random number table method.While keeping the same clinical routine treatment in both groups,the study group used high-frequen-cy rTMS and the control group used pseudo-stimulation intervention.The levels of Hamilton depression scale(HAMD-17),Barthel index(BI),serum neurotransmitter 5-hydroxytryptamine(5-HT),norepinephrine(NE)and clinical efficacy of the two groups were compared before and after the intervention.Results After the intervention,the HAMD-17 score of the study group was lower than that of the control group,and the BI score,5-HT and NE levels were higher than those of the control group,with statistically significant differences(P＜0.05).The clinical efficacy of the study group was better than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion High-frequency rTMS has a better ap-plication effect on PSD patients.High-frequency rTMS can improve patients'depressive symptoms,daily life activities,and serum content of 5-HT and NE.This protocol can be popularized and applied in clinic.
关键词
卒中后抑郁/高频重复经颅磁刺激/情绪/血清神经递质水平
Key words
Post-stroke depression/High-frequency repetitive transcranial magnetic stimulation/Emotion/Serum neuro-transmitter levels
维普
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