Effect of Ranibizumab combined with laser photocoagulation in the treat-ment of retinal vein occlusion secondary macular edema
Objective To investigate the effect of Ranibizumab combined with laser photocoagulation on visual acuity in patients with retinal vein occlusion(RVO)secondary macular edema(ME).Methods A total of 84 patients(84 eyes)with RVO secondary ME treated in the First Hospital of Nanchang from January 2020 to December 2022 were selected as the study objects,and they were divided into control group(42 cases)and observation group(42 cases)according to random number table method.The control group was treated with laser photocoagulation,and the observation group was treated with Ranibizumab combined with laser photocoagulation.The best corrected visual acuity(BCVA),central macular thickness(CMT),intraocular pressure,vascular endothelial growth factor(VEGF),treatment effect of fundus retinal hemorrhage and complications were compared between the two groups.Results After treatment,the BCVA,CMT and VEGF in observation group were lower than those in control group,and the total effective rate(92.86％)was higher than that in control group(76.19％),the differences were statistically significant(P＜0.05).There was no significant difference in intraocular pressure between the two groups after treatment(P＞0.05).No complications such as retinal detachment,vitreous hemorrhage and in-traocular infection were found in all patients.Only one case of transient intraocular hypertension was found in the observa-tion group.Conclusion In patients with RVO secondary ME,the combination of Ranibizumab and laser photocoagulation can reduce the levels of CMT and VEGF,improve the visual acuity and retinal hemorrhage of patients,and have little effect on the intraocular pressure of patients with no increase in complications,and the clinical application is safe.
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