Objective To investigate the effect of non-background dose of Oxycodone controlled intravenous analgesia in elderly patients after hip replacement.Methods A total of 80 elderly patients undergoing joint hip replacement under sub-arachnoid-epidural anesthesia treated in Nanjing Yi Min Hospital from January 2021 to December 2022 were selected as the study objects.They were divided into SF group(40 cases)and Q group(40 cases)according to random number method.The SF group was given Sufentanil 0.5 μg/kg and 100 ml controlled intra venous analgesia,and the Q group was given Oxy-codone 0.5 mg/kg and 100 ml controlled intra venous analgesia,and both groups have non-background dose,and the analgesia time were set for 48 h.The use of controlled intra venous analgesia at 2 h(T2),6 h(T6),12 h(T12),24 h(T24)and 48 h(T48)after surgery,resting and exercise visual analogue scale(VAS)score,incidence of delirium,duration of delirium,length of hospital stay,and incidence of adverse reactions(pruritus,nausea and vomiting,hypoxemia,bradycardia)were compared between the two groups.Results There was no significant difference in T2,T6,T12,T24,T48 VAS score at resting and exercise between the two groups(P＞0.05).The postoperative delirium rate in group Q(5.0％)was lower than that in group SE(22.0％),and the difference was statistically significant(P＜0.05).The duration of delirium in Q group([1.89±0.35]h)was shorter than that in SF group([2.89±1.58]h),and the difference was statistically significant(P＜0.05).The hospital-ization time of Q group([11.45±2.55]d)was shorter than that of SF group([14.78±2.22]d),and the difference was statisti-cally significant(P＜0.05).The total adverse reaction rate of Q group was lower than that of SF group,and the difference was statistically significant(P＜0.05).Conclusion Non-background dose of Oxycodone intravenous analgesia has a good safety and efficacy in elderly hip arthroplasty analgesia,can reduce the occurrence of postoperative delirium.
OxycodoneNon-background doseCon-trolled intravenous analgesiaElderly hip replacementPostoperative analgesiaDelirium
维普
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