Objective To understand the epidemiological characteristics and etiological surveillance results of hand foot mouth disease(HFMD)in children in Lishui from 2020 to 2022,so as to provide scientific basis for the prevention and con-trol of HFMD.Methods The incidence data of HFMD in Lishui City were collected by infectious disease reporting informa-tion management system,and the epidemic characteristics were analyzed.At the same time,real-time quantitative PCR was used to detect the etiology of 1 558 samples collected to explore the dynamic changes of the pathogen spectrum of HFMD enterovirus from 2020 to 2022.Results A total of 13 611 cases of HFMD disease were reported in Lishui from 2020 to 2022.1 032 enterovirus nucleic acid positive cases were detected in 1 558 etiological samples,with a total positive rate of 66.24％.Among them,5 cases of enterovirus 71(EV71),322 cases of coxsackievirus A16(CoxA16),494 cases of coxsackievirus A6(CoxA6),63 cases of coxsackievirus A10(CoxA10),and 148 cases of other types,the total positive rate was 0.32％,20.67％,31.71％,4.04％and 9.5％,respectively.Only 5 cases of EV71 were detected in 2021,the positive rates of CoxA16 were 2.44％,21.54％and 36.42％respectively,and the detection peaks were from January to August and November to December in 2022,the positive rates of CoxA6 were 49.78％,33.44％and 12.76％respectively,and the detection peak was from Au-gust to December 2020,CoxA10 was detected only in 2020 and 2021,with 4.00％and 7.23％,respectively.Conclusion The epidemic characteristics of HFMD in other years are similar to those in previous years,except that the epidemic month of HFMD was postponed in 2020.From 2020 to 2022,the main enterovirus types of HFMD in Lishui were CoxA16 and CoxA6,and the dominance of CoxA6 was gradually replaced by CoxA16.CoxA16 is the focus of prevention and control work in the next step.
Hand foot and mouth diseaseEpidemic characteristicsPathogen spectrum analysis
维普
万方数据
