Long non-coding RNA(lncRNA)is a class of non-coding RNA molecules with lengths exceeding 200 nu-cleotides.They play a crucial role in regulating gene expression at various levels,such as chromatin modification,transcrip-tional control,and post-transcriptional processing,thereby influencing the development and progression of tumors.Investi-gating the molecular regulatory mechanisms of lncRNAs in cancer has become a hot topic in recent years.Existing research has confirmed that LINC01503 is a newly discovered long non-coding RNA in squamous cell carcinoma.It exhibits signifi-cant overexpression in various human cancers,including colorectal cancer,ovarian cancer,lung cancer,and glioblastoma.Its abnormal expression is closely associated with poor patient prognosis.Furthermore,LINC01503 is involved in promoting malignant biological behaviors of tumor cells,including cell proliferation,migration,invasion,and anti-apoptosis,through mechanisms such as ceRNA regulation,epithelial-mesenchymal transition,participation in multiple signaling pathways,and epigenetic modifications.Understanding the role of LINC01503 in cancer can have implications for the diagnosis,treatment,and prognosis assessment of related malignancies.This article provides a comprehensive review of the expression and molecular regulatory research progress of LINC01503 in relevant tumors.
Long non-coding RNALINC01503TumorMolecular regulation
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