Clinical observation of Indobufen combined with acupoint application in preventing venous thrombosis in nephrotic syndrome
Objective To study and analyze the efficacy of Indobufen combined with acupoint application in preventing ve-nous thrombosis in nephrotic syndrome.Methods The clinical data of 90 patients with nephrotic syndrome admitted to Jiu-jiang Hospital of Traditional Chinese Medicine from June 2021 to January 2023 were retrospectively analyzed.According to the different treatment methods,they were divided into group A,B and C,with 30 cases in each group.Patients in group A were treated with Indobufen,patients in group B were treated with acupoint application on the basis of group A,and patients in group C were treated with Aspirin Enteric-coated Tablets.The clinical efficacy,coagulation indexes(activated partial thromboplastin time[APTT],prothrombin time[PT],fibrinogen[FIB]level,D-dimer[D-D]),renal indexes(blood urea ni-trogen[BUN]and serum creatinine[SCr]),adverse reactions and incidence of venous thrombosis were compared among the three groups.Results After treatment,there were statistically significant differences in clinical efficacy,coagulation indexes and BUN levels among the three groups(P＜0.05).The total effective rate of group B was higher than that of group A and group C,and the difference was statistically significant(P＜0.017).The APTT and PT of group B were longer than those of group A and group C,while FIB,D-D and BUN were lower than those of group A and group C,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions among the three groups(P＞0.05).There was statistically significant difference in the incidence of venous thrombosis among the three groups(P＜0.05).However,there was no significant difference between any two groups(P＞0.017).Conclusion In the treatment of nephrotic syndrome,indobufen combined with acupoint application can reduce the risk of venous thrombo-sis,promote local blood supply,and has good safety.
万方数据
维普
