Objective To explore the correlation between changes in lymphocyte subsets and renal function after kidney transplantation.Methods A total of sixty postoperative kidney transplant patients admitted to Zhongshan City People's Hos-pital from January 2019 to December 2022 were selected as the study subjects.Peripheral venous blood samples were col-lected from patients at different time points after surgery to observe renal function indicators,lymphocyte subgroup percent-ages,and absolute values at 15 days,1,3,and 6 months after surgery.The correlation between T lymphocyte subgroup per-centages and absolute values and renal function was analyzed.Results There was no statistically significant difference in the blood creatinine levels of patients at four time points after surgery(P＞0.05).The urea nitrogen,percentage of lymphocyte subsets,and absolute values at four postoperative time points were compared,and the differences were statistically signifi-cant(P＜0.05).There was a positive correlation between blood creatinine and urea nitrogen(r=0.472,P＜0.05),while the percentage and absolute value of lymphocyte subsets are not correlated with blood creatinine(P＞0.05).The percentages of helper T lymphocytes(CD3+CD4+)and suppressor T lymphocytes(CD3+CD8+)were positively and negatively correlated with urea nitrogen(r=0.247,-0.269,P＜0.05).The absolute values of total T lymphocytes(CD3+)and CD3+CD4+were negatively correlated with urea nitrogen(r=-0.259,-0.094,P＜0.05).Conclusion The dynamic changes of lymphocyte subsets in pa-tients after kidney transplantation are closely related to renal function.Clinical needs to strengthen monitoring of lymphocyte subset levels and renal function indicators in patients after surgery,and provide guidance for adjusting subsequent treatment plans.
维普
万方数据
