Analysis of the effect of prophylactic antibiotic therapy on neonates of perinatal group B streptococcal infection
Objective To analyze the clinical characteristics of pregnant women and newborns infected with group B strep-tococcus(GBS)during the perinatal period,and to explore the impact of implementing GBS screening and antibiotic preven-tive treatment on early onset GBS infection in newborns.Methods A retrospective study was conducted on 169 pregnant women and newborns infected with GBS during the perinatal period at the Zigong First People's Hospital from October 2018 to September 2022.The infected pregnant women were divided into observation group(94 cases)and control group(75 cas-es)according to the time of antibiotic use before delivery.The observation group received intravenous antibiotics for 72 con-secutive hours before delivery or an interval of ≥ 4 hours between intravenous antibiotics and delivery.The control group re-ceived intravenous antibiotics before delivery with an interval of＜4 hours and no treatment.The pregnancy health care rate,35-37 week of pregnancy screening rate,incidence of body temperature ≥ 37.5 ℃ before and after delivery,incidence of fetal distress,incidence of premature rupture of membranes ≥ 8 hours,incidence of neonatal hospitalization ≥ 5 days,in-cidence of body temperature ≥ 37.5 ℃ within 1 week of admission,incidence of antibiotic treatment time greater than 3 days,positive rate of binaural secretion culture,incidence of neonatal pneumonia between two groups of pregnant women The incidence of neonatal sepsis and neonatal meningitis.Results The 35-37 week of pregnancy screening rate and the pregnancy health care rate of tertiary medical institutions in the observation group were higher than those in the control group,with significant differences(P＜0.05).The incidences of body temperature ≥ 37.5℃,fetal distress and premature rupture of membranes ≥8 hours before and after delivery in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).The incidences of hospitalization time ≥ 5 days,body temper-ature ≥ 37.5 ℃ within 1 week of admission,antibiotic treatment time ≥ 3 days,positive rate of two-ear secretion culture and neonatal pneumonia in the neonatal observation group were lower than those in the control group,the differences were statis-tically significant(P＜0.05).There were no cases of neonatal septicemia and neonatal meningitis in the two groups.Conclu-sion The screening of GBS infection and the prophylactic application of antibiotics can effectively reduce the incidence of GBS early infection in newborns.
Group B streptococcusPerinatal pregnant womenNewbornAntibiotic
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维普
