Correlation analysis between serum Quetiapine concentration and thyroid function indexes in patients with schizophrenia
Objective To investigate the correlation between the serum concentration of Quetiapine and thyroid function in-dex in patients with schizophrenia treated with Quetiapine,and to explore the clinical significance of serum concentration of Quetiapine on thyroid function reduction.Methods A total of 142 patients with schizophrenia admitted to the Nanning Fifth People's Hospital from January 2018 to December 2019 were selected as the research subjects.General information and laboratory examination indicators of the patients were collected.Thyroid stimulating hormone(TSH),triiodothyronine(T3),thyroxine(T4),free triiodothyronine(FT3)and free thyroxine(FT4)were used as thyroid function indexes to analyze the relationship between serum Quetiapine concentration and thyroid function.Results After Quetiapine treatment,TSH level increased,T3,T4,FT3 and FT4 levels decreased compared with treatment before(P＜0.05).Pearson correlation analysis showed that serum Quetiapine concentration was positively correlated with TSH level(P＜0.05),and negatively correlated with T4and FT4 levels(P＜0.05).The analysis of the ROC curve showed the sensitivity and specificity of Quetiapine on thy-roid function reduction were 50％and 81.5％,respectively,and the AUC was 0.669.Conclusion Serum thyroid hormone levels in patients with schizophrenia treated with Quetiapine are correlated with serum concentration of Quetiapine,which can cause reduced thyroid function,suggesting that blood concentration and serum thyroid hormone levels should be monitored in patients with schizophrenia treated with Quetiapine.
万方数据
维普
