Diagnostic value of quantitative detection of serum procalcitonin in bacte-rial bloodstream infection
Objective To investigate the predictive value of serum procalcitonin(PCT)quantitative detection for the diag-nosis of bacterial bloodstream infection,providing a basis for the clinical rational empirical use of antibiotics.Methods Clinical data of patients undergoing blood culture in Yangjiang City Hospital of Traditional Chinese Medicine from May 2019 to June 2022 were retrospectively analyzed,among which 235 patients with positive blood culture and bacterial blood-stream infection were taken as the bloodstream infection group,and 240 patients with negative blood culture were taken as the control group.PCT detection was performed in all patients,PCT levels of the two groups were compared,and ROC curve was drawn to analyze the predictive value of PCT levels on bloodstream infection.Then the blood flow infection group was divided into 100 Gram-positive bacteria group(G+group)and 135 Gram-negative bacteria group(G-group)according to pathogenic bacteria types.The diagnostic value of PCT levels in two groups for bacterial bloodstream infections with different pathogenic bacteria types were compared.According to the different modes of infection,235 cases of bloodstream infection in this study were set as systemic infection group,and 180 cases of wound secretion infection collected during the same pe-riod were set as local infection group.The PCT levels of the two groups were compared.Results The level of PCT in blood flow infection group was higher than that in control group,and the difference was statistically significant(P＜0.05).When the PCT was 0.64 ng/ml as the best cut-off point,the specificity,sensitivity,negative predictive value and positive predictive value of PCT in the diagnosis of bacterial bloodstream infection were 88％,64％,45％and 85％,respectively.The PCT level of G-group was higher than that of G+group,and the difference was statistically significant(P＜0.05).When PCT level was 0.73 ng/ml as the optimal cut-off point,the sensitivity,specificity,negative predictive value and positive predictive value of the diagnosis of G-bacterial infection were 72％,82％,46％and 84％,respectively.G+bacteria were mainly Staphylococcus aureus and Staphylococcus epidermidis,while Escherichia coli and Klebsiella pneumoniae were the most common among G-bacteria infections.The PCT level in the systemic infection group was higher than that in the local infection group,and the difference was statistically significant(P＜0.05).When the PCT level was 0.12 ng/ml as the cut-off value,the sensitivity and specificity of the diagnosis of systemic infection were 92％and 80％,respectively.Conclusion PCT level detection is bene-ficial for the early diagnosis of bloodstream infections and can provide a basis for the clinical rational use of antimicrobial drugs,thereby reducing patient mortality.
万方数据
维普
