Efficacy and safety of repeated transcranial magnetic stimulation com-bined with Duloxetine in the treatment of depression
Objective To research the efficacy and safety of repetitive transcranial magnetic stimulation(rTMS)combined with Duloxetine in the treatment of depression.Methods A total of 100 patients with depression admitted to the Third Peo-ple's Hospital of Hulunbuir from May 2022 to May 2023 were selected as the research subjects.They were divided into ob-servation group and control group using computer program,with 50 patients in each group.The control group was treated with Duloxetine Hydrochloride Enteric-coated Capsules.On the basis of receiving the same antidepressant medication treatment,the observation group was added with rTMS treatment.The clinical efficacy,Hamilton depression scale(HAMD-17)and incidence of adverse reactions were compared between the two groups.Results The treatment effectiveness rate of the observation group was higher than that of the control group,with statistically significant difference(P＜0.05).Af-ter two weeks of treatment,the HAMD-17 score of observation group patients was lower than that of the control group,with statistically significant difference(P＜0.05).There was no statistically significant difference in the incidence of adverse re-actions between two groups(P＞0.05).Conclusion Compared with antidepressants alone,rTMS combined with antidepres-sants was more effective and safer.
Major depressive disorderRepetitive transcranial magnetic stimulationDuloxetineEfficacySecurity
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