Research on the mechanism of Sanhuang Lotion in the treatment of eczema
Objective To explore the potential molecular mechanism and predict targets of Sanhuang Lotion for against eczema through molecular docking technology and network pharmacology.Methods The active compounds and potential targets of Sanhuang Lotion were gathered from the Traditional Chinese Medicine Systems Pharmacology Database and Anal-ysis Platform(TCMSP),while the relevant targets for eczema were obtained from databases such as PubMed,GeneCards,and DisGeNET.Cytoscape 3.8.0 software was used to create a network diagram representing the relationship between drugs,compounds,targets,and disease.Autodock Vina was used for molecular docking.Results A total of 85 active compounds and 241 related target proteins were obtained from Sanhuang Lotion,3 057 eczema-related targets were screened.The total of 57 active ingredients in Sanhuang Lotion were identified,along with 117 potential targets,for treating eczema.Molecular docking results showed that the binding energy,which indicated that the target proteins had a great affinity with the main functional components.Conclusion From the perspective of network pharmacology,this study predicted the mechanisms of action of Sanhuang Lotion in treating eczema,indicating that Sanhuang Lotion in treating eczema had the characteristics of multiple ingredients,multiple targets and multiple pathways,which providing reference for basic research and clinical ap-plication in the treatment of skin diseases such as eczema.
万方数据
维普
