Effect of Atorvastatin on oxidative stress in diabetes mellitus type 2 pa-tients with cardiac autonomic neuropathy
Objective To investigate the effect of Atorvastatin on oxidative stress in patients with diabetes mellitus type 2(T2DM)and cardiac autonomic neuropathy.Methods A total of eighty T2DM patients with DAN admitted to the Fourth Af-filiated Hospital of Nanchang University from June 2021 to December 2022 were selected as the study objects.They were divided into a control group(40 cases)and an observation group(40 cases)by random number table method.Both groups re-ceived symptomatic treatments such as lipid-lowering,antihypertensive,and glycemic control.The control group received o-ral metformin tablets,and based on this,the observation group was additionally treated with atorvastatin.Blood glucose,blood lipids(total cholesterol[TC],triglycerides[TG]),and oxidative stress indicators between two groups before and after 2 months of treatment were compared.Results The average blood glucose levels after treatment in the two groups were lower than before treatment in the same group,and the differences were statistically significant(P＜0.05).After treatment,the TG([3.08±0.49]mmol/L)and TC([5.06±0.71]mmol/L)in the observation group were lower than those in the control group([3.95±0.61]mmol/L and[6.88±0.85]mmol/L),with statistical significances(P＜0.05).After treatment,the level of malondialdehyde(MDA)in the observation group was lower than that in the control group,while the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH Px)were higher than those in the control group,with statistical signifi-cances(P＜0.05).Conclusion Oxidative stress reaction is common in T2DM patients with DAN.Antioxidant treatment with Atorvastatin is beneficial to alleviate oxidative stress,improve blood lipid level,and promote recovery,which is worth exten-sive clinical application.
Diabetes mellitus type 2Cardiac autonomic neuropathyAtorvastatinOxidative stress
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维普
