Effect of Helicobacter pylori eradication therapy on gastrointestinal hor-mone levels and quality of life in patients with constipation-type irritable bowel syndrome
Effect of Helicobacter pylori eradication therapy on gastrointestinal hor-mone levels and quality of life in patients with constipation-type irritable bowel syndrome
Objective To investigate the effect of Helicobacter pylori(Hp)infection on gastrointestinal hormones and quality of life in patients with constipation-type irritable bowel syndrome(IBS-C).Methods A total of 158 patients with IBS-C and positive 14C breath test from July 2021 to June 2022 in Guangzhou Red Cross Hospital were selected as research objecys,they were divided into control group(64 cases)and observation group(94 cases)according to whether they received Hp eradication therapy.The control group was given conventional treatment,and the observation group was given Hp eradication therapy on the basis of conventional treatment.The level of somatostatin(SS),plasma motilin(MTL),gastrin-17(G-17),vasoactive intestinal peptide(VIP)and irritable bowel syndrome-quality of life(IBS-QOL)scores between the two groups were compared before and after different treatments.Results Before treatment,there were no significant differences in gastrointestinal hormone level and IBS-QOL score between observation group and control group(P＞0.05).The SS,G-17 and VIP levels after treatment were lower than before treatment,and the MTL level was higher than before treatment,with statistical significance(P＜0.05).After treatment,the SS,G-17 and VIP levels in observation group were lower than those in control group,and the MTL level was higher than that in control group,with statistical significance(P＜0.05).After treatment,the IBS-QOL scores and total scores in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Hp infection may be associated with the onset of IBS-C,and eradicating Hp treatment can regulate gastrointestinal hormone levels,which can help improve the quality of life of such patients.
关键词
幽门螺杆菌/便秘型肠易激综合征/胃肠道激素/生活质量评分
Key words
Helicobacter pylori/Constipation-type irri-table bowel syndrome/Gastrointestinal hormones/Quality of life score
维普
万方数据