Clinical study on the significance of perioperative hypersensitive C-reactive protein and other related indexes in the treatment of Standford Type B aortic dissection
Clinical study on the significance of perioperative hypersensitive C-reactive protein and other related indexes in the treatment of Standford Type B aortic dissection
Objective To investigate the effects of hypersensitive C-reactive protein(hs-CRP),D-dimer(D-D)and procalcitonin(PCT)on the prognosis of thoracic aortic endovascular repair in Standford Type B aortic dissection(TBAD).Methods A total of 80 TBAD patients who underwent thoracic aortic endovascular repair(TEVAR)in the First People's Hospital of Fuzhou from April 2017 to March 2022 were selected as the study objects.Serum levels of High sensitivity C-reactive protein(hs-CRP),D-dimer(D-D)and procalcitonin(PCT)were detected 1 day before surgery and 7 days after surgery.Patients were divided into good prognosis group and poor prognosis group according to the prognosis.Serum hs-CRP,D-D and PCT levels of the two groups were compared 1 day before surgery and 7 days after surgery,and the correlation between serum hs-CRP,D-D and PCT levels and the prognosis of the patients was analyzed.Results Of the 80 patients,63 cases(78.75％)had good prognosis(good prognosis group)and 17 cases(21.25％)had poor prognosis(poor prognosis group).Serum hs-CRP,D-D and PCT levels in 2 groups were significantly higher on day 7 after surgery than on day 1 before surgery(P＜0.05).Serum hs-CRP,D-D and PCT levels in the good prognosis group were lower than those in the poor prognosis group 1 day before and 7 days after surgery,with statistical significances(P＜0.05).The results of logistic regression model analysis showed that serum preoperative 1 day hs-CRP(β=0.617,OR=1.854,95％CI=1.217-2.696),D-D(β=0.639,OR=1.895,95％CI=1.841-2.635),and PCT(β=0.554,OR=1.741,95％CI=1.547-3.052)levels and postoperative 7 days hs-CRP(β=0.892,OR=2.440,95％CI=1.251-4.761),D-D(β=0.797,OR=2.219,95％CI=1.669-3.141),and PCT(β=0.604,OR=1.829,95％CI=1.058-2.969)levels were the influencing factors of the prognosis of TBAD patients treated with TEVAR.Conclusion Monitoring the levels of serum hs-CRP,D-D and PCT in perioperative period is valuable for prognostic judgment of TBAD patients treated with TEVAR.
关键词
Standford/B型/主动脉夹层/腔内治疗/围手术期/超敏C反应蛋白/D-二聚体/降钙素原
Key words
Standford B type/Aortic dissection/Endovascular therapy/Perioperative/Hypersensitive C-reactive protein/D-dimer/Calcitonin original
维普
万方数据