Spinal cord injury(SCI)is a common and serious central nervous system disease in spinal orthopedics.Its pathogenesis is complex and its incidence is on the rise.So far,no specific diagnosis and treatment plan has been formed in clinic.Yin-yang imbalance is the basis of spinal cord injury.After spinal cord injury,microglia are stimulated and polarized into Ml and M2 microglia through classical activation state and alternative activation state.These two different states play different roles in the process of spinal cord injury,corresponding to the yin and yang balance and mutual opposition in the theory of yin and yang in Chinese medicine.Studies have shown that microglia not only play an important role in the nutri-tion and maintenance of neurons,but also play an important role in the repair and regeneration of spinal cord injury.There-fore,the treatment of spinal cord injury should be based on this,adjust the spinal cord environment to achieve the balance of yin and yang,and then promote the spinal cord nerve repair.Based on the theory of yin and yang in Chinese medicine,this paper discusses the role of microglia in inflammation after spinal cord injury and provides theoretical basis for the clinical treatment of SCI.
关键词
脊髓损伤/小胶质细胞活化/阴阳理论/炎症反应
Key words
Spinal cord injury/Microglial activation/Theory of yin-yang/Inflammatory response
维普
万方数据