Diabetic kidney disease(DKD)is a chronic kidney disease caused by diabetes,which will eventually lead to end-stage renal disease.The application of data mining to the research of DKD can more effectively find potential and valu-able rules or connections from random and fuzzy data.Network pharmacology is based on systems biology,through the con-struction of"drug-target-disease"network to elaborate drug action on disease targets and pathways.At present,data mining technology and network pharmacology have become popular methods for the study of traditional Chinese medicine in the treatment of DKD.This paper summarizes the data mining and network pharmacology in the study of traditional Chinese medicine syndrome and medication law of traditional Chinese medicine in the treatment of DKD,and the application of net-work pharmacology in the treatment of DKD.The related research of data mining and network pharmacology in the diagnosis and treatment of DKD is summarized.In order to provide guidance and reference for further research on the treatment of DKD with traditional Chinese medicine through data mining and network pharmacology.