Objective To investigate the effect of moxibustion combined with Irbesartan Tablets on diabetic nephropathy(DKD)patients in stage Ⅲ and Ⅳ.Methods A total of 80 DKD patients treated in Jiujiang Hospital of Traditional Chinese Medicine from August 2020 to August 2021 were selected as the study objects,and were divided into control group and ob-servation group by random number table method,with 40 cases in each group.The control group was treated with basic treatment and oral Irbesartan Tablets,and the observation group was added with moxibustion.The clinical efficacy,tradi-tional Chinese medicine syndrome score,blood glucose level,inflammatory factor level,biochemical indexes and adverse re-actions were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).The traditional Chinese medicine syn-drome scores of the observation group after treatment were lower than those of the control group,and the differences were statistically significant(P＜0.05).In terms of blood glucose,fasting blood glucose(FPG)and 2 h postprandial blood glucose(2 hPG)were lower than those in control group,with statistical significances(P＜0.05).In terms of inflammatory factors,the levels of tumor necrosis factor α(TNF-α),hypersensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6)were lower than those of control group,with statistical significances(P＜0.05).In terms of biochemical indexes,the levels of urea nitrogen(BUN),blood creatinine(Scr),24 h urinary protein quantity(mALB),urinary microalbumin(MAU),urinary albu-min/creatinine ratio(ACR)and urinary retinol binding protein(RBP)were lower than those of control group,and the differ-ences were statistically significants(P＜0.05).No obvious adverse reactions were observed in the two groups.Conclusion The application of moxibustion combined with Irbesartan Tablets in the treatment of patients with DKD Ⅲ and Ⅳ can im-prove blood glucose level and renal function,relieve clinical symptoms,reduce inflammatory reaction,with exact effect and good safety,which is worthy of promotion.
关键词
糖尿病肾病/艾灸/厄贝沙坦片/血糖水平/炎症因子水平/生化指标
Key words
Diabetic nephropathy/Moxibustion/Irbesartan Tablets/Blood glucose levels/Levels of inflammatory factors/Biochemical indicators
维普
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