首页|基于脂组学方法分析不同危险因素的脑卒中患者预后的研究

基于脂组学方法分析不同危险因素的脑卒中患者预后的研究

Study on the prognosis of stroke patients with different risk factors based on lipotomic method

扫码查看
目的 探讨基于脂组学方法分析不同危险因素的脑卒中患者预后的研究.方法 回顾性分析九江市第一人民医院2021年2月至2023年2月收治的120例缺血性脑卒中(AIS)患者的临床资料治疗3个月后将其按预后情况分为良好组(n=82)和不良组(n=38).分析患者年龄、性别、吸烟史、饮酒史、高血压、高脂血症、糖尿病、脑卒中家族遗传史、总胆固醇(TC)、三酰甘油(TG)、糖化血红蛋白(HbA1c)、低密度脂蛋白胆固醇(LDL-C)水平对AIS患者预后的影响.结果 全部纳入研究的120例AIS患者中,有38例患者出现预后不良,发生率为31.67%;有82例预后良好,发生率为68.33%.单因素分析结果提示,两组性别、吸烟史、饮酒史、高血压、高脂血症、糖尿病、脑卒中家族遗传史比较,差异无统计学意义(P>0.05);两组患者年龄、TC、TG、HbA1c以及LDL-C比较,差异有统计学意义(P<0.05).多因素分析结果提示,年龄(β=0.266,OR=1.304,95%CI=1.136~1.498)、HbA1c(β=0.838,OR=2.312,95%CI=1.269~4.212)、LDL-C(β=1.662,OR=5.269,95%CI=2.178~12.745)是 AIS 患者预后不良的危险因素(P<0.05).结论 年龄、HbA1c、LDL-C是AIS患者预后不良的危险因素.可根据上述因素进行针对性干预,以期减少AIS患者预后不良的发生率.
Objective To investigate the prognostic of stroke patients with different risk factors based on lipotomic method.Methods The clinical data of 120 patients with acute ischemic stroke(AIS)admitted to Jiujiang First People's Hospital from February 2021 to February 2023 were retrospectively analyzed,after 3 months of treatment,the patients were divided into good group(n=82)and bad group(n=38)according to prognosis.The effects of age,gender,smoking history,drinking histo-ry,hypertension,hyperlipidemia,diabetes,family history of stroke,total cholesterol(TC),triglyceride(TG),glycated hemoglobin(HbA1c)and low-density lipoprotein cholesterol(LDL-C)levels on the poor prognosis of AIS patients were an-alyzed.Results Among all 120 AIS patients included in the study,38 patients had poor prognosis,with an incidence of 31.67%,and 82 patients had good prognosis,with an incidence of 68.33%.The results of univariate analysis showed that there were no significant differences in gender,smoking history,drinking history,hypertension,hyperlipidemia,diabetes and family genetic history of stroke between the two groups(P>0.05).There were significant differences in age,TC,TG,HbA1c and LDL-C between the two groups(P<0.05).Multiple factors analysis results suggest that age(β=0.266,OR=1.304,95%CI=1.136-1.498),HbA1c(β=0.838,OR=2.312,95%CI=1.269-4.212),LDL-C(β=1.662,OR=5.269,95%CI=2.178-12.745)were risk factors for poor prognosis in AIS patients,and the differences were statistically significant(P<0.05).Conclusion Age,HbA1c and LDL-C are risk factors for poor prognosis of AIS patients.Targeted interventions can be carried out according to the above factors to reduce the incidence of poor prognosis in AIS patients.

StrokeGlycated hemoglobinLow-density lipoprotein cholesterolPrognosisLipidomics

刘建平、高慧、张莲红

展开 >

江西省九江市第一人民医院神经内科,江西九江 332000

脑卒中 糖化血红蛋白 低密度脂蛋白胆固醇 预后 脂组学

江西省卫生健康委科技项目

202311468

2024

中国当代医药
中国保健协会 当代创新(北京)医药科学研究院

中国当代医药

影响因子:1.215
ISSN:1674-4721
年,卷(期):2024.31(13)
  • 23