The high incidence rate and mortality rate of type 2 diabetes mellitus have caused huge social and economic losses worldwide,and are still on the rise.Lifestyle intervention may be the most practical and cost-effective way to deal with this persistent epidemic.Time-restricted feeding,as an emerging dietary intervention measure,refers to limit the daily food consumption window within 4-10 hours,which is a special form of intermittent fasting.Recently,a series of studies have proved that time-restricted feeding can effectively prevent and alleviate the progress of type 2 diabetes mellitus and the oc-currences of complications through circadian clock,intestinal microbes,skeletal muscle mitochondria,inflammation,lipid circulation and other ways,with high compliance and no serious side-effects.However,there is still no relevant summary regarding the specific mechanism of its effects in China.Therefore,this article reviews the impact of time-restricted feeding on glucose metabolism in type 2 diabetes mellitus and its mechanism of action,providing reference for the clinical applica-tion of diet programs and the formulation of the best diet program suitable for the current situation in China.
关键词
2型糖尿病/限时进食/昼夜时钟/肠道微生物/炎症因子/氧化应激/脂质循环
Key words
Type 2 diabetes mellitus/Time-restricted feeding/Circadian clock/Gut microbiota/Inflammatory factor/Ox-idative stress/Lipid circulation
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