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嘉兰的现代研究进展

Progress in modern research on Gloriosa superba L.

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嘉兰为百合科嘉兰属植物,大量学术研究报道了嘉兰根和块茎中主要含秋水仙碱、β-Lumi(-)-秋水仙碱,r-光秋水仙碱、1,2-二去甲基秋水仙碱、2,3-二去甲基秋水仙碱、3-去甲基秋水仙碱等七种生物碱类化学成分.另外,也有研究报道指出嘉兰全株植物均还含有糖苷类、黄酮类、类固醇、萜类、皂苷类、甾体类、酚类、树脂类化学物质.现代多项药理学研究指出嘉兰提取物具有抗痛风、抗菌以及抗胰腺癌、抗结肠癌、抗口腔癌、抗宫颈癌、抗肝癌、抗肺癌、抗乳腺癌等多种抗癌作用;此外,嘉兰还具有抗银屑病、抗炎镇痛、抗氧化、抗溃疡等多种药理活性,但大多还未明确其作用机制,有待深入研究.由于嘉兰在现代研究中逐渐成为秋水仙碱的主要来源,因此对嘉兰中秋水仙碱的含量测定方法研究也成为了对嘉兰研究利用的一个重要方面,主要的方法有高效薄层色谱法(HPTLC)、液相高分辨高精密度质谱法(LC-HRMS)、高效液相色谱法(HPLC).笔者从化学成分、药理作用、质量研究等多个方面对嘉兰的相关研究进行综述,为嘉兰的进一步开发利用提供科学的理论依据.
Gloriosa superba L.belongs to the genus of Liliaceae.A large number of academic studies have reported that there are mainly seven alkaloids in the roots and tubers of Gloriosa superba L.,such as colchicine,β-lumi(-)-colchicine,r-colchicine,1,2-dimethylcolchicine,2,3-demethylcolchicine,3-demethylcolchicine and so on.In addition,it has been reported that the whole plant of Gloriosa superba L.also contains glycosides,flavonoids,steroids,terpenoids,saponins,steroids,phenols and resins.A number of modern pharmacological studies have pointed out that Gloriosa superba L.extract has a variety of anticancer effects,such as anti-gout,antibacterial,anti-pancreatic cancer,anti-colon cancer,a nti-oral can-cer,anti-cervical cancer,anti-liver cancer,anti-lung cancer,anti-breast cancer and so on.Gloriosa superba L.also has a variety of pharmacological activities,such as anti-dandruff disease,anti-inflammatory and analgesic,anti-oxidation,anti-ulcer and so on,but most of them are not clear about their mechanism and need to be further studied.As Gloriosa su-perba L.has gradually become the main source of colchicine in modern research,the determination method of colchicine in Gloriosa superba L.has also become an important aspect of the research and utilization of Gloriosa superba L..The main methods are high performance thin layer chromatography(HPTLC),liquid phase high resolution high precision mass spectrometry(LC-HRMS),high performance liquid chromatography(HPLC).The author summarizes the related studies of Gloriosa superba L.from the aspects of chemical composition,pharmacological action,quality research and so on,in order to provide a scientific theoretical basis for the further development and utilization of Gloriosa superba L..

Gloriosa superba L.Chemical constituentsPharmacological actionQuality studies

兰家琴、龚云麒、刘一丹、刘军锋

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云南中医药大学中药学院,云南昆明 650500

昆药集团股份有限公司研究院,云南昆明 650100

嘉兰 化学成分 药理作用 质量研究

2024

中国当代医药
中国保健协会 当代创新(北京)医药科学研究院

中国当代医药

影响因子:1.215
ISSN:1674-4721
年,卷(期):2024.31(17)
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