首页|癌胚抗原、中性粒细胞和淋巴细胞比值、单核细胞和淋巴细胞比值、血小板和淋巴细胞比值联合检测在胃癌诊断中的价值

癌胚抗原、中性粒细胞和淋巴细胞比值、单核细胞和淋巴细胞比值、血小板和淋巴细胞比值联合检测在胃癌诊断中的价值

Value of combined detection of carcinoembryonic antigen,neutrophil and lymphocyte ratio,monocyte and lymphocyte ratio,platelet and lympho-cyte ratio in the diagnosis of gastric cancer

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原文链接
  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的 本研究旨在探讨联合检测中性粒细胞和淋巴细胞比值(NLR)、单核细胞和淋巴细胞比值(MLR)、血小板和淋巴细胞比值(PLR)与癌胚抗原(CEA)在胃癌患者中的诊断价值.方法 回顾性收集2015年1月至2020年9月广西医科大学附属武鸣医院首次收治入院并经术后病理活检诊断为胃癌的209例患者及同期进行健康体检的209例健康人群的血常规、CEA等指标进行分析.采用ROC曲线分析NLR、MLR、PLR和CEA单独及联合检测对胃癌的诊断价值.另外比较胃癌不同特征分组间各个指标的连续变量.结果 胃癌患者NLR、MLR、PLR及CEA值均高于健康对照组,差异有统计学意义(P＜0.05).NLR、MLR、PLR及CEA单独诊断胃癌的灵敏度分别为37％、60％、39％、43％,特异度分别为 92％、88％、91％、78％,ROC 曲线下面积(AUC)分别为 0.65、0.80、0.69、0.63.NLR、MLR、PLR及CEA联合检测灵敏度、特异度和AUC分别上升至69％、88.00％、0.84.肿瘤有远处转移的胃癌患者NLR、MLR、PLR值较高,差异有统计学意义(P＜0.05).结论 NLR、MLR、PLR及CEA的联合检测在胃癌诊断中具有较高的灵敏度和特异度,可提高胃癌诊断的正确率,同时能预测肿瘤的迁移变化,有助于胃癌患者的早发现、早诊疗.
Objective The aim of this study was to investigate the diagnostic value of combined detection of neutrophil and lymphocyte ratio(NLR),monocyte and lymphocyte ratio(MLR),platelet and lymphocyte ratio(PLR)and carcinoembryonic antigen(CEA)in patients with gastric cancer.Methods Blood routine and CEA were retrospectively collected and analyzed from 209 patients who were first admitted and admitted to Wuming Hospital of Guangxi Medical University and diagnosed with gastric cancer by postoperative pathological biopsy from January 2015 to September 2020 and 209 healthy people who underwent health checkups during the same period.ROC curve was used to analyze the diagnostic value of NLR,MLR,PLR and CEA alone and in combination for gastric cancer.In addition,the continuous variables of each index between different characteristic subgroups of gastric cancer were compared.Results The values of NLR,MLR,PLR and CEA were higher in gastric cancer patients than in healthy controls,and the differences were statistically significant(P＜0.05).The sensitivity of NLR,MLR,PLR and CEA alone in the diagnosis of gastric cancer were 37％,60％,39％,43％,and the specificity were 92％,88％,91％,78％,respectively,and the area under the ROC curve(AUC)were 0.65,0.80,0.69,0.63.The sensitivity,specificity and AUC of combined NLR,MLR,PLR and CEA increased to 69％,88.00％,0.84,respec-tively.Gastric cancer patients with distant metastasis of the tumor had higher values of NLR,MLR,PLR,and the difference was statistically significant(P＜0.05).Conclusion The combined detection of NLR,MLR,PLR and CEA has high sensitivi-ty and specificity in the diagnosis of gastric cancer,which can improve the correct rate of diagnosis of gastric cancer,and at the same time can predict the migratory changes of the tumor,which can help the early detection and diagnosis of gastric cancer patients.

Gastric cancerNeutrophil/lymphocyte ratioMonocyte/lymphocyte ratioPlatelet/lymphocyte ratioCarci-noembryonic antigen

丁仁彬、凌云、苏莹莹、陆雨、梁小恒、李泰阶

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广西医科大学附属武鸣医院医学检验科,广西南宁 530199

广西医科大学第二附属医院急诊科,广西南宁 530007

胃癌 中性粒细胞和淋巴细胞比值 单核细胞和淋巴细胞比值 血小板和淋巴细胞比值 癌胚抗原

2024

中国当代医药
中国保健协会 当代创新（北京）医药科学研究院

中国当代医药

影响因子：1.215
ISSN：1674-4721
年,卷(期)：2024.31(18)