Objective To investigate the clinical effect of Qinggan Lishhi Granules combined with Entecavir in the treatment of hepatobiliary damp heat type hepatitis B cirrhosis.Methods A total of 100 patients with hepatobiliary damp heat type hepatitis B cirrhosis treated in Zhaoqing Hospital of Traditional Chinese Medicine from January 2021 to April 2023 were selected as the study objects,and divided into control group(50 cases)and study group(50 cases)according to random drawing method.The control group was treated with Entecavir,and the study group was treated with Entecavir combined with Qinggan Lishi Granules.The clinical efficacy,biochemical indexes(alanine aminotransferase,aspartate aminotransferase,total bilirubin),imaging features,hepatitis B virus DNA negative conversion rate and adverse reactions were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P＜0.05).After treatment,the levels of alanine transaminase,aspartate transaminase and total bilirubin in the study group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the internal diameter of the portal vein,the maximum velocity of the portal vein,the internal diameter of the splenic vein and the maximum velocity of the splenic vein in the study group were lower than those in the control group,with statistical significances(P＜0.05).The negative rate of hepatitis B virus DNA in the study group was higher than that in the control group,and the difference was statistically significant(P＜0.05).There were 4 cases of adverse reactions in the study group and 6 cases in the control group.There was no statistical significance in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Qinggan Lishi Granules combined with Entecavir can effectively inhibit hepatitis B virus replication and improve liver function in the treatment of hepatobiliary damp heat type hepatitis B cirrhosis with high safety.
Qinggan Lishi GranulesEntecavirHepatitis BCirrhosisLiver function
维普
万方数据
