Diagnostic value of red blood cell distribution width-SD,uric acid and cystatin C combined detection in post-stroke cognitive impairment in a-cute ischemic stroke patients
Objective To investigate the value of red blood cell distribution width-SD,uric acid and cystatin C in predicting post-stroke cognitive impairment(PSCI)in patients with acute ischemic stroke.Methods Clinical data of 161 acute ischemic stroke patients admitted to the Department of Neurology,Huaian Hospital Affiliated to Yangzhou University from March 2022 to March 2023 were retrospectively collected.Red blood cell distribution width-SD,interleukin-6,hypersensitive C-reactive protein,triglyceride,cholesterol,cystatin C,uric acid and other levels were detected the next day after admission.Patients were followed up 3 months after discharge and were divided into PSCI group and post-stroke non-cognitive impairment(NPSCI)group according to Montreal cognitive assessment(MoCA)scores.The clinical data of the two groups were compared,and the risk factors of PSCI after ischemic stroke were analyzed by binary logistic regression.Receiver operating characteristic(ROC)curve was prepared,and the predictive value of red blood cell distribution width-SD,uric acid and cystatin C on PSCI were analyzed by area under the curve(AUC).Results The years of education in PSCI group were lower than those in NPSCI group,red blood cell distribution width-SD,cystatin C and uric acid levels were higher than those in NPSCI group,with statistical significances(P＜0.05).Multivariate logistic regression analysis showed that red blood cell distribution width-SD(β=0.080,OR=1.084,95％CI:1.026-1.145),cystatin C(β=2.341,OR=10.387,95％CI:2.734-29.458),uric acid(β=0.021,OR=1.021,95％CI:1.013-1.029)were risk factors for PSCI in pa-tients with acute ischemic stroke(P＜0.05).ROC curve results show that,the AUC of red blood cell distribution width-SD,cystatin C,uric acid and the combined levels predicted the occurrence of PSCI in patients with acute ischemic stroke were 0.745,0.773,0.863 and 0.921,suggesting that combined testing of the three indexes has certain predictive value for PSCI in patients with acute ischemic stroke.Conclusion Red blood cell distribution width-SD,uric acid and cystatin C are risk fac-tors for PSCI in patients with acute ischemic brain,and have certain predictive value for PSCI after ischemic stroke.
Red blood cell distribution widthUric acidCystatin CPost-stroke cognitive impairment
万方数据
维普
