首页|鳖甲煎丸联合运动康复对非酒精性脂肪性肝病患者的临床研究

鳖甲煎丸联合运动康复对非酒精性脂肪性肝病患者的临床研究

Clinical study of Biejia Decoction Pills combined with exercise rehabilita-tion on patients with nonalcoholic fatty liver disease

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目的 探讨鳖甲煎丸联合运动康复对非酒精性脂肪性肝病(NAFLD)患者的临床效果.方法 选取2022年1月至2023年1月江西省九江市第一人民医院收治的62例NAFLD患者作为研究对象,按照随机数字表法分为对照组(31例)和观察组(31例).两组均严格控制膳食热量的摄入,对照组在此基础上采用运动康复治疗,观察组在对照组基础上加用鳖甲煎丸治疗,两组均连续治疗8周.比较两组的肝脏脂肪含量、体重指数(BMI)、肝功能、血脂水平及不良反应.结果 两组患者治疗前的肝脏脂肪含量、BMI及血清甘油三酯(TG)、总胆固醇(TC)、丙氨酸转氨酶(ALT)、γ-谷氨酰转肽酶(γ-GT)、天冬氨酸转氨酶(AST)水平比较,差异无统计学意义(P>0.05);两组患者治疗后的肝脏脂肪含量、BMI及TG、TC、ALT、γ-GT、AST水平均低于本组治疗前,差异有统计学意义(P<0.05);观察组治疗后的肝脏脂肪含量、BMI及TG、TC、ALT、γ-GT、AST水平均低于对照组,差异有统计学意义(P<0.05);两组均未见明显不良反应.结论 NAFLD患者采用鳖甲煎丸联合运动康复治疗具有较好的效果,利于减轻肝脏内脂肪沉积,纠正血脂异常,改善肝功能,降低BMI,安全性好,值得推广.
Objective To investigate the clinical effect of Biejia Decoction Pills combined with exercise rehabilitation on patients with non-alcoholic fatty liver disease(NAFLD).Methods A total of 62 patients with NAFLD admitted to Jiu Jiang NO.1 People's Hospital from January 2022 to January 2023 were selected as the study objects,and they were divided into control group(31 cases)and observation group(31 cases)according to random number table method.Both groups strictly controlled the intake of dietary calories,the control group was treated with exercise rehabilitation on the basis of this,and the observation group was treated with Biejia Decoction Pills on the basis of the control group,both groups were treated for 8 weeks.The liver fat content,body mass index(BMI),liver function,blood lipid level and adverse reactions were compared between the two groups.Results There were no significant differences in liver fat content,BMI,serum triglyceride(TG),total choles-terol(TC),alanine transaminase(ALT),γ-glutamyl transpeptide(γ-GT)and aspartate transaminase(AST)levels between two groups before treatment(P>0.05).After treatment,the liver fat content,BMI,TG,TC,ALT,γ-GT and AST levels of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the liver fat content,BMI,TG,TC,ALT,γ-GT and AST levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no obvious adverse reactions in both groups.Conclusion Biejia Decoction Pills combined with exercise rehabilitation therapy for NAFLD patients has a good effect,which is beneficial to reduce liver fat deposition,correct dyslipidemia,improve liver function,reduce BMI,and is safe,worthy of promotion.

Nonalcoholic fatty liver diseaseBiejia Decoction PillsExercise rehabilitationLiver fat contentBody mass indexLiver functionBlood lipid levelAdverse reaction

张宇、柯华菁

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江西省九江市第一人民医院肝病科,江西九江 332001

江西省九江市第一人民医院康复医学科,江西九江 332001

非酒精性脂肪性肝病 鳖甲煎丸 运动康复 肝脏脂肪含量 体重指数 肝功能 血脂水平 不良反应

江西省中医药管理局科技计划项目

2022B821

2024

中国当代医药
中国保健协会 当代创新(北京)医药科学研究院

中国当代医药

影响因子:1.215
ISSN:1674-4721
年,卷(期):2024.31(21)